The Impact of Probiotic Intervention on the Gut Microbiota and Bowel Function of Patients With Prophylactic Ileostomy for Ultra Low Rectal Cancer -a Multicenter Randomized Controlled Trial
This study aims to propose a novel, easy-to-operate intervention strategy that effectively improves defecation function after stoma reversal and to assess its impact on the gut microbiota.The efficacy and safety of antegrade placement of probiotics into the distal deserted intestine during prophylactic stoma to improve bowel function after stoma reversal were evaluated through randomized controlled clinical trials.Observing the changes in gut microbiota during the prophylactic stoma period, the impact of probiotics on the structure of gut microbiota, and exploring the correlation between gut genera and bowel function after stoma reversal.
• Age between 18 and 75 years
• Ultra low rectal cancer meeting the indication for Intersphincteric Resection (ISR) surgery
• Underwent a prophylactic ileostomy
• Scheduled for stoma reversal surgery within 6 months after the ISR procedure
• Digestive tract reconstruction achieved via either hand-sewn or stapled coloanal anastomosis
• Patient has a strong preference for undergoing sphincter-preserving surgery
• Capable of understanding and willing to provide signed informed consent