Investigation of in Vivo Endogenous and/or Exogenous Production of Phenolic Metabolites in People With an Ileostomy Using an Oral (Poly)Phenol Challenge Test
Plant foods contain natural compounds called (poly)phenols, which may help lower the risk of heart and metabolic diseases. However, people differ greatly in how they absorb and process these compounds, partly because most (poly)phenols are broken down by gut bacteria in the colon. This makes it difficult to know exactly which metabolites come from the diet, and which are produced by the body. Studying people with an ileostomy provides a unique opportunity to understand how much is absorbed in the small intestine and how these compounds are transformed. This will help us better understand individual responses to dietary (poly)phenols.
• Currently living with an ileostomy
• \> 1-year post-operative
• Aged 18 - 75 years
• BMI 18 - 28 kg/m2
• Males and females (not currently pregnant / lactating)
• Non-smokers (including vaping)
• Not taking antibiotic therapy 3 months prior to the study
• No phytochemical supplement usage 2 weeks prior to study start.
• Free-living (i.e. not housebound)
• No participation in other biomedical studies 3 months prior.