Research on the Diagnosis and Treatment of Angle Closure Glaucoma With Abnormal Lens Zonular

Status: Unknown
Location: See location...
Study Type: Observational
SUMMARY

Angle-closure glaucoma is the main type of glaucoma in China, which is divided into acute and chronic angle-closure glaucoma. Previous studies from our group have found that, in lens excision combined with glaucoma surgery, accounted for 46.2% of patients were ligament abnormalities, such as lens subluxation with suspensory ligament relaxation. And it was more common in acute angle-closure glaucoma (55.8%). In acute angle-closure glaucoma, approximately 55.2% of suspensory ligament abnormalities were not diagnosed preoperatively depend on UBM and slit lamp examinations. The purpose of this study was to find a better preoperative diagnosis method of the suspensory ligament abnormality, and to observe the influence of the suspensory ligament abnormality on the occurrence, development and treatment effect of acute angle-closure glaucoma. We plan to collect patients with acute angle-closure glaucoma with monocular onset and exclude traumatic, secondary glaucoma and a history of intraocular surgery. The onset eyes were treated with combined operation, and divided into two groups according to the presence or absence of suspensory ligament abnormalities. The fellow eyes were treated with laser peripheral iridectomy, and followed examination, including UBM, anterior-segment OCT, and IOL master 700, before and after bow excitation test. Then follow up patients every six months. Ultimately, the fellow eyes will be treated with combined surgery after 2.5 years or the fellow eyes occur acute angle-closure glaucoma. In the end, we evaluate the sensitivity and specificity of each index, and the influence of suspensory ligament abnormality on angle-closure glaucoma progression.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 45
Maximum Age: 79
Healthy Volunteers: f
View:

• age: 45-79 years old, BCVA\>0.3.

• Clinical diagnosis of angle-closure glaucoma, with 19mm\<axial length\<24mm.

• Clinical diagnosis of age-related cataract (as control group), with 22mm\<axial length\<26mm.

• All the surgeries were finished by the same two experienced ophthalmologists.

• The first operated eye was included for observation.

Locations
Other Locations
China
Beijing Tongren Hospital
RECRUITING
Beijing
Contact Information
Primary
Chunyan Qiao, MD
chunyan_qiao@163.com
86-176-1067-8637
Time Frame
Start Date: 2020-11-01
Completion Date: 2024-12-31
Participants
Target number of participants: 250
Treatments
Angle closure glaucoma patients with or without abnormal zonular.
We observe the zonular during surgery, and divide patients into two groups according to their zonular, including with or without abnormal zonular.
Patients with age-related cataract.
We observe the zonular during surgery, and divide patients into two groups according to their zonular, including with or without abnormal zonular.
Sponsors
Leads: Chunyan Qiao_2021

This content was sourced from clinicaltrials.gov