Effectiveness of an Oral Methylprednisolone Taper Following Primary Total Knee Arthroplasty
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 1
SUMMARY
This study aims to evaluate the effectiveness of an oral methylprednisolone taper in reducing postoperative pain, opioid consumption, and nausea following primary total knee arthroplasty (TKA).
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:
• Any patient undergoing primary TKA with a diagnosis of osteoarthritis
• \> 18 years old
• Willingness to undergo randomization
• Patients who will be home by postoperative day (POD) #1 to start the dosing schedule that day (includes both ambulatory and POD #1 discharge patients)
Locations
United States
New York
Columbia University Medical Center
RECRUITING
New York
Contact Information
Primary
Jacqueline Lenahan
jl5092@cumc.columbia.edu
917-583-2885
Time Frame
Start Date: 2025-06-20
Estimated Completion Date: 2027-06-20
Participants
Target number of participants: 130
Treatments
Experimental: Patients receiving oral methylprednisolone
Patients receiving a six-day oral methylprednisolone taper (21 tablets, 4 mg each) in addition to standard multimodal pain management
No_intervention: Patients receiving standard pain management without the taper
Patients receiving standard pain management without the taper
Related Therapeutic Areas
Sponsors
Leads: Columbia University