Exhaled Breath Particles as a Clinical Indicator for Acute and Chronic Rejection After Lung Transplantation

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

Lung transplantation (LTx) is the only effective treatment for patients with end stage lung disease. Of the major organs transplanted, survival following LTx is the lowest with a mean of 5 years. Despite improvements, primary graft dysfunction (PGD) remains the leading cause of early mortality and contributes to the development of chronic lung allograft dysfunction (CLAD) that remains the leading cause of late mortality. Earlier detection of rejection after LTx is of substantial importance as it would improve the possibilities of treatment and could increase survival. The investigators have shown in previous work that exhaled breath particles (EBP) reflect the composition of respiratory tract lining fluid (RTLF). EBP and particle flow rate (PFR) can be used as non-invasive methods for early detection and monitoring of airway diseases such as acute respiratory distress syndrome (ARDS). It has also been shown that the particle flow prolife after lung transplantation differs between patients who develop PGD and those who do not and that the composition of EBP differs between patients with and without bronchiolitis obliterans syndrome (BOS), an obstructive form of CLAD. Samples of EBP and measurements of PFR will be collected from lung transplanted patients. Membranes with EBP will be saved for molecular analysis. The investigators aim to identify potential particle flow patterns and biomarkers for earlier detection of rejection after lung transplantation.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 16
Maximum Age: 75
Healthy Volunteers: f
View:

• Patients who have undergone LTx at Skåne University Hospital, SUS Lund

Locations
Other Locations
Sweden
Skåne University Hospital
RECRUITING
Lund
Contact Information
Primary
Sandra Lindstedt, MD, PhD
sandra.lindstedt_ingemansson@med.lu.se
+46737220580
Time Frame
Start Date: 2018-09-18
Estimated Completion Date: 2026-09
Participants
Target number of participants: 150
Treatments
LTx rejection
Lung transplanted patients with acute or chronic rejection
LTx non-rejection
Lung transplanted patients without any form of rejection
Sponsors
Leads: Lund University Hospital

This content was sourced from clinicaltrials.gov