Comparison of Segmentectomy Versus Lobectomy for Lung Adenocarcinoma ≤ 2cm With Micropapillary and Solid Subtype Negative by Intraoperative Frozen Sections: A Prospective and Multi-center Randomized Controlled Trial Study
This study aims to evaluate the non-inferiority in recurrence-free survival and overall survival of segmentectomy compared with lobectomy in patients with lung adenocarcinoma ≤ 2 cm with micropapillary and solid subtype negative by intraoperative frozen sections.
• Patient aged 20-79 years old, both male or female;
• Tumor size \<= 2cm on preoperative CT scan;
• Peripheral solitary nodule or the associated lesion is MIA or less invasive lesion;
• Preoperative CT indicated that the nodules were non-pure glass nodules (consolidation to tumor ratio \>= 0.25);
• Intraoperative frozen section confirmed invasive lung adenocarcinoma with micropapillary and solid subtype negative (\<= 5%);
• Intraoperative frozen section indicated the resection margins was free of tumor cells;
• Lung function could withstand both lung segmentectomy and lobectomy (FEV1 \> 1.5L or FEV1% \>= 60%);
• Eastern Cooperative Oncology Group, 0 to 2;
• Volunteer to participate the trial and sign the informed consent, able to comply with the follow-up plan and other program requirements.