External Vacuum Expansion: Evaluation in Breast Reconstructive Surgery

Status: Recruiting
Location: See all (3) locations...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This multicentre randomized controlled trial aims to evaluate a new breast reconstruction technique- autologous fat transfer (AFT). Female patients with breast cancer schedule to receive a mastectomy (or having undergone mastectomy in the past) will be randomized to undergo breast reconstruction with either AFT with the EVEBRA device(intervention group) or AFT without the EVEBRA device (control group). AFT will be evaluated in terms of volume, quality of life, aesthetic result, complications and oncological safety.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 23
Maximum Age: 69
Healthy Volunteers: f
View:

• Female

• Age 23-69

• BMI 18-35 - stable weight, no fluctuations

• Have undergone a total mastectomy at least 3 months prior the study, whether therapeutic or prophylactic, whether unilateral or bilateral, with no resection of the pectoralis muscle

• Agrees to have reconstruction at the time of study involving only autologous fat grafting (AFT)

• Assessed by surgeon to have enough donor fat

• Passes a 20-minutes tolerance test with EVEBRA Device. (Patient will be fitted, instructed on the use, and given the EVEBRA Device to try in the office for 20 minutes. She passes if she tolerates its use, feels comfortable wearing it, and is able to comply with the required wear of the device.)

Locations
Other Locations
Netherlands
Amsterdam University Medical Center (VUMC)
RECRUITING
Amsterdam
Ziekenhuis groep Twente (ZGT)
RECRUITING
Hengelo
Maastricht University Medical Center+
RECRUITING
Maastricht
Contact Information
Primary
Maud Rijkx, MD, MsC
maud.rijkx@mumc.nl
+31 (0) 43 38 723 08
Time Frame
Start Date: 2021-07-12
Estimated Completion Date: 2026-10
Participants
Target number of participants: 90
Treatments
Active_comparator: AFT+ EVEBRA device (intervention arm)
Before and after the AFT surgery, patients are required to wear the EVEBRA expansion device for a total duration of 4 weeks. Thereafter patients will receive a PexyBra over the reconstructed breast.~Pre-operatively patients are required to wear the device for a total of 200 hours.
No_intervention: AFT without EVEBRA device (control arm)
Patients will receive the AFT treatment for total reconstruction without the requirement of wearing the EVEBRA device.
Related Therapeutic Areas
Sponsors
Leads: Maastricht University Medical Center
Collaborators: ZonMw: The Netherlands Organisation for Health Research and Development

This content was sourced from clinicaltrials.gov