Intraoperative Hypotension in Pancreatoduodenectomy: A Randomized Trial of General Versus Combined Anesthesia
This randomized clinical trial compares the hemodynamic effects of general anesthesia versus combined general anesthesia (thoracic epidural) in patients undergoing pancreatoduodenectomy. The primary aim is to assess the incidence of intraoperative hypotension and related adverse events. Secondary outcomes includes vasopressor requirements, transfusion needs, postoperative complications, intensive care unit admission, hospital length of stay, and mortality.
• Signed written informed consent.
• Patients scheduled for elective pancreatoduodenectomy at National Institute of Medical Sciences and Nutrition Salvador Zubirán.
• No contraindications for neuroaxial anesthesia (epidural catheter placement), including:
‣ Generalized or localized infection at the puncture site.
⁃ Thrombocytopenia.
⁃ Coagulation disorders.
⁃ Intracranial hypertension.
⁃ Patient refusal.