Efficacy of Apixaban in Treating Portal Vein Thrombosis Occurring More Than One Year After Laparoscopic Splenectomy and Azygoportal Disconnection
The purpose of this study is to determine whether Apixaban is effective and safe in the treatment of portal vein thrombosis Occurring more than one year after laparoscopic splenectomy and azygoportal disconnection.
• A clinical, radiological, or histologic diagnosis of cirrhosis of any etiology.
• Portal hypertension bleeding .
• Splenomegaly with secondary hypersplenism.
• No evidence of portal vein thrombosis by ultrasound evaluation and angio-CT prior to surgery.
• Underwent laparoscopic splenectomy at our center.
• Orally received 2.5 mg of apixaban (CTTQ, Nanjing, China) twice daily or a 100 mg aspirin tablet (Bayer, Leverkusen, Germany) once daily for 6 months from POD 3.
• subcutaneous injections of low molecular weight heparin sodium (CSBio, Hebei, China) were administered for 5 days from POD 3
• Oral dipyridamole (Henan Furen, Henan, China) at a dosage of 25 mg, administered three times daily for 3 months from POD 3.
• Had no imaging evidence (Doppler ultrasound or CT) of portal vein thrombosis during postoperative months 6 to 12.
⁃ Developed portal vein thrombosis after 12 months post-surgery.
⁃ Provided informed consent to participate in the study.