• Subject is 18 years of age or older, or of legal age to give informed consent per state or national law.

• Baseline NIHSS score obtained prior to randomization must be equal or higher than 10 points.

• Subjects with no significant pre-stroke functional disability (modified Rankin scale 0 - 2).

• Subjects suspected of acute ischemic stroke with an estimated arrival time at a stroke center (clinical investigational site participating in this study) \< 6 hours from symptom onset. Symptom onset is defined as point in time the patient was last known well (at baseline).

• Informed consent obtained from patient or his or her legally designated representative (if locally required).

• Angiography suite immediately available.

• Endovascular treatment team immediately available (Neurologist, Neurointerventionist, Anesthesiologist, Nursing, Technicians as per local standard practice)