PeRforation EVents During ENdovascular Therapy for Acute Ischemic Stroke (PREVENT) - Registry

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

A large, worldwide study called PREVENT is looking at a complication that can happen during a stroke treatment called thrombectomy. This complication is a perforation of a blood vessel. The investigators aim to: 1. Find what factors make this perforation more likely. 2. Understand why the perforation happens by looking closely at images taken during the procedure. 3. Create a simple way to classify these perforations to help doctors decide how to treat them right away. 4. Improve the emergent treatment of vessel perforation to stop the bleeding rapidly. 5. Provide data to guide decision whether thrombectomy should be continued or aborted after the event of vessel perforation. 6. Develop a safer way to perform thrombectomy. Investigators will compare the results collected for patients where perforation happened with those where perforation did not happen.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Age ≥ 18 years at time of thrombectomy

• Acute ischemic stroke with occlusion of one or several intracranial arteries and subsequent thrombectomy.

• Target cohort: Occurrence of intracranial perforation during thrombectomy with evidence of contrast extravasation in at least one diagnostic angiography series.

• Comparison cohort: No perforation during thrombectomy. Every patient in the comparison group is matched to one patient in the target population. Matching will be carried out with respect to age, gender, participating center and location of the vascular occlusion.

Locations
Other Locations
Switzerland
University Hospital Basel
RECRUITING
Basel
Contact Information
Primary
Victor Schulze-Zachau, MD
Victor.schulze-zachau@usb.ch
+41 61 328 56 32
Backup
Marios N Psychogios, Prof. Dr.
Marios.psychogios@usb.ch
+41 61 328 59 36
Time Frame
Start Date: 2024-12-02
Estimated Completion Date: 2027-09
Participants
Target number of participants: 1000
Treatments
Perforation during thrombectomy
The target cohort includes 500 patients where vessel perforation occured during Thrombectomy.
No perforation during thrombectomy
The comparison cohort includes 500 patients, matched to the target cohort, where vessel perforation did not occur during Thrombectomy.
Related Therapeutic Areas
Sponsors
Leads: University Hospital, Basel, Switzerland

This content was sourced from clinicaltrials.gov