Endovascular Treatment for Mild Ischemic Stroke Due to Acute Large Vessel Occlusion in the Anterior Circulation: A Multicenter Prospective Registry

Status: Recruiting
Location: See all (9) locations...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Explore the effectiveness and safety of emergency endovascular treatment in patients with mild ischemic stroke due to acute large vessel occlusion in the anterior circulation, identified through perfusion imaging.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: f
View:

• Age 18-80 years old;

• Symptoms onset or last known well to randomization is within 24 hours.

• Clinical diagnosis of acute ischemic stroke due to anterior circulation intracranial large vessel occlusion (LVO) (including intracranial internal carotid artery \[ICA\], middle cerebral artery \[MCA\] M1 segment, MCA M2 segment, with or without ipsilateral extracranial ICA occlusion) confirmed on Computerized tomography angiography (CTA) or Magnetic resonance imaging angiography (MRA) ;

• Baseline NIHSS score \<6 before randomization (including cases with NIHSS ≥6 at onset but improves before randomization);

• ASPECTS score ≥6 based on Non-contrast CT (NCCT) before randomization;

Locations
Other Locations
China
Ganzhou People's Hospital
RECRUITING
Ganzhou
Jiamusi Central Hospital
RECRUITING
Jiamusi
Gansu Provincial Hospital of Traditional Chinese Medicine
RECRUITING
Lanzhou
Lishui Central Hospital
RECRUITING
Lishui
The First Affiliated Hospital of Nanchang University
RECRUITING
Nanchang
Shenyang First People's Hospital
RECRUITING
Shenyang
Songyuan Jilin Oilfield Hospital
RECRUITING
Songyuan
Taizhou First People's Hospital
RECRUITING
Taizhou
Zhangzhou Municipal Hospital
RECRUITING
Zhangzhou
Contact Information
Primary
Wenhuo Chen, MD
13806906089@126.com
+8613806906089
Backup
Tingyu Yi, MD
siyuyufen@163.com
+8615859635985
Time Frame
Start Date: 2017-01-01
Estimated Completion Date: 2024-12-30
Participants
Target number of participants: 200
Treatments
Experimental: Experimental Group
The operator will choose the optimal endovascular treatment strategy and device based on the patient's condition and clinical experience. This may include, but is not limited to, stent retriever thrombectomy, aspiration thrombectomy, intra-arterial thrombolysis, balloon angioplasty, stent implantation, etc. The endovascular treatment plan and relevant time points will be accurately recorded. The patient will receive the best medical treatment according to current local clinical research standards during and after the procedure.
No_intervention: Control Group
Patients will receive the best medical treatment according to local clinical research standards, including antiplatelet agents, anticoagulants, thrombolysis, etc., excluding any endovascular treatment. In the event of disease progression defined as neurological deterioration leading to an increase in NIHSS ≥4 points and excluding non-stroke factors within 24 hours, remedial endovascular treatment may be taken, including but not limited to stent retriever thrombectomy, aspiration thrombectomy, intra-arterial thrombolysis, balloon angioplasty, stent implantation, etc.
Related Therapeutic Areas
Sponsors
Leads: Wen-huo Chen

This content was sourced from clinicaltrials.gov