Trial of Rescue Endovascular Treatment for Progressive Acute Mild Ischemic Stroke With Basilar Artery Occlusion With Extended Time Window
A prospective, multicenter, open-label, blinded-endpoint, randomized controlled trial to evaluate whether best medical management (BMM) combined with endovascular therapy (EVT) improves neurological outcomes compared to BMM alone in patients with progressive acute mild ischemic stroke due to basilar artery occlusion within an extended time window.
• Age ≥18 years.
• Symptoms and signs consistent with basilar artery ischemia.
• Basilar artery or vertebral artery occlusion confirmed by computed tomography angiography (CTA), magnetic resonance angiography (MRA), or digital subtraction angiography (DSA); if vertebral artery occlusion is present, it should completely block blood flow along the basilar artery.
• First-time onset meeting the criteria for mild ischemic stroke diagnosis: NIHSS score \<6.
• Symptom progression within 7 days of the first onset.
• Symptom progression: NIHSS score increase ≥4 points or consciousness level increase ≥2 points from the initial NIHSS score.
• Time from symptom onset to randomization \>24 hours.
• Symptom progression to randomization time ≤24 hours.
• NIHSS score ≥10 before randomization.
⁃ pc-ASPECTS before randomization ≥ 6
⁃ The patient or their family members are willing to comply with the protocol requirements and data collection procedures, understand, and sign the informed consent form.