Female Fertility Preservation Using Ovarian Tissue Cryopreservation Before Highly Gonadotoxic Cancer Treatment

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Background: Due to the remarkable improvement in treatments these last decades, long term survival can be expected in more than 80% of childhood cancer patients. Unfortunately, cancer treatments can be harmful to the gonads and can affect reproductive and endocrine functions. While loss of fertility is a major concern for most patients, only the experimental option of ovarian tissue cryopreservation can be proposed to prepubertal girls with a high risk of infertility. For pubertal patient, cryopreservation of mature oocytes after ovarian stimulation can be offered if oncological treatment debut can be delayed. As it is often not possible, ovarian tissue cryopreservation can also be offered. Primary aims \- To cryopreserve ovarian tissue of pre or peripubertal patient who will be receiving highly gonadotoxic oncological treatment. Secondary aims * To create a database in order to record clinical and biological follow-up data * To pool resources with Fertisave Registry * To create a research biobank for future research projects Multicentric study: HUG, CHUV

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 2 months
Maximum Age: 18
Healthy Volunteers: f
View:

• Pediatric pre ou peripubertal patient aged 2 months and older

• Patient presenting high risk of infertility because of gonadotoxic treatments (i.e. high dose of alkylating agents, ovarian irradiation, total body irradiation)

• Multidisciplinary team consensus in favour to proposition to cryopreserve ovarian tissue.

Locations
Other Locations
Switzerland
Geneva University Hospitals
RECRUITING
Geneva
CHUV
RECRUITING
Lausanne
Contact Information
Primary
Fabienne Gumy-Pause, Dr
fabienne.gumypause@hcuge.ch
Time Frame
Start Date: 2015-06
Estimated Completion Date: 2100-01
Participants
Target number of participants: 100
Treatments
Experimental: ovarian tissue cryopreservation
Related Therapeutic Areas
Sponsors
Leads: Gumy-Pause Fabienne

This content was sourced from clinicaltrials.gov