The Role of Inflammation and Fibrosis in the Development of Conduction Disorders After Transcatheter Aortic Valve Implantation
Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY
Prediction of conduction disorders (CDs) in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI) is an important and complex process with a significant impact on patient outcomes. The goal of this observational prospective trial is to investigate the role of pre-procedural values of systemic biomarkers of inflammation and fibrosis in the prediction of new-onset CDs and permanent pacemaker implantation (PPI) in patients undergoing the TAVI procedure.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:
• Written consent to participate in the trial
• Diagnosis of severe AS according to current European Society of Cardiology (ESC) guidelines for valvular heart disease
Locations
Other Locations
Croatia
Clinical Hospital Center Rijeka
RECRUITING
Rijeka
Contact Information
Primary
Gordana Bačić, MD
gordana.bacic@uniri.hr
+38551407320
Time Frame
Start Date: 2024-12-12
Estimated Completion Date: 2026-08
Participants
Target number of participants: 102
Treatments
The group with new-onset TAVI-related conduction disorders (CDs)
The group will include patients with new-onset CD or PPI detected during the index hospitalization and a 3-month follow-up period.
The group without new-onset TAVI-related conduction disorders (CDs)
The group will include patients without new-onset CD or PPI detected during the index hospitalization and a 3-month follow-up period.
Related Therapeutic Areas
Sponsors
Collaborators: University of Rijeka, Medical Faculty
Leads: Clinical Hospital Center Rijeka