An Evaluation of the Relationship Between Abnormal Myocardial Perfusion and Diastolic Dysfunction in Sickle Cell Disease Using PET (Stress-Rest) Myocardial Perfusion Imaging (MYPERS)
There is limited information on what causes injury to the heart in individuals with Sickle Cell Disease (SCD). Researchers in this study want to see if decreased blood flow to the heart during stress could be causing the heart damage seen in SCD patients. They also want to test people who don't have SCD to see if their hearts react the same way under stress. Primary Objective * To estimate the coronary flow reserve (CFR) (also referred to as myocardial perfusion reserve), as measured by PET stress-rest myocardial perfusion imaging, in SCD patients with and without diastolic dysfunction, and healthy controls. Secondary Objectives * To investigate the relationship between decreased CFR (quantified with PET stress- rest myocardial perfusion imaging) and presence of abnormal diastolic parameters
• 18 to 21 years of age
• Black
• Diagnosis of SCD of HbSS and HbSβ0thalassemia genotypes
• Three or more abnormal diastolic parameters (based on guidelines by American Society of echocardiography)
• 18 to 21 years of age
• Black
• Diagnosis of SCD of HbSS and HbSβ0thalassemia genotypes
• Two or less abnormal diastolic parameters
• 18 to 21 years of age
• Black
• Two or less abnormal diastolic parameters