The Triad of Nutrition, Intestinal Microbiota and Rheumatoid Arthritis (TASTY)
Status: Recruiting
Location: See all (2) locations...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The main goal of this trial is to investigate whether a dietary intervention based on a typical Mediterranean Diet enriched with fermented foods (MedDiet+) can impact gut microbiota and RA-related outcomes.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:
• RA patients (ACR/EULAR2010 criteria)
• Age \>18-years
• Disease duration \>1-year
• Active disease (DAS28 \> 2.6units)
• On stable medication for 12 weeks
• Low/medium MedDiet adherence (PREDIMED\<10)
• Willing to comply with study protocol
Locations
Other Locations
Portugal
Faculdade Medicina de Lisboa
RECRUITING
Lisbon
Unidade Local de Saude de Santa Maria
RECRUITING
Lisbon
Contact Information
Primary
Catarina Sousa Guerreiro, PhD
cfguerreiro@medicina.ulisboa.pt
+351 217 999 474
Time Frame
Start Date: 2023-01-02
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 100
Treatments
Experimental: MedDiet+ intervention
The 12-week nutritional intervention includes a personalized dietary plan based on the MedDiet+ pattern, educational resources, food basket deliveries, and clinical culinary workshops, all developed and monitored weekly by registered dietitians. The nutritional plan includes the food portions of each food group in agreement with the MedDiet recommendations for the adult population, complemented with fermented foods including kefir (provided for daily consumption) and kombucha (provided for consumption 2x/week).
Active_comparator: General dietary recommendations
This group receives a flyer with general recommendations on a healthy diet based on the Portuguese brief guidance for healthy eating in primary health care at baseline
Related Therapeutic Areas
Sponsors
Collaborators: Gulbenkian Institute for Molecular Medicine
Leads: Lisbon Academic Medical Center - Centro Académico de Medicina de Lisboa