Acetylsalicylic Acid for Postpartum Preeclampsia: A Pilot Randomized Trial
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2
SUMMARY
The purpose of this research study is to evaluate the effect of low-dose aspirin on recovery from severe preeclampsia (a high blood pressure disorder of pregnancy) among women who have given birth. We hypothesize that taking aspirin for the first week after giving birth will enhance recovery from preeclampsia by decreasing the levels of a protein called soluble fms-like tyrosine kinase (sFlt-1), which is thought to be a main contributor to the development of preeclampsia, and speeding up return to a normal blood pressure.
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Healthy Volunteers: f
View:
• Preeclampsia with severe features diagnosed during delivery admission, as defined by ACOG criteria.
• Pre- and postnatal care provided by the Long Beach Memorial Ob/Gyn resident or Maternal-Fetal Medicine clinic.
Locations
United States
California
Miller Children's and Women's Hospital, Long Beach/MemorialCare Long Beach
RECRUITING
Long Beach
Contact Information
Primary
Megan C Oakes, MD MSCI
moakes2@memorialcare.org
562-997-8510
Backup
Ashten B Waks, MD MSPH
awaks@memorialcare.org
562-997-8510
Time Frame
Start Date: 2023-07-26
Estimated Completion Date: 2026-12
Participants
Target number of participants: 86
Treatments
Experimental: Standard blood pressure control plus aspirin 81 mg
Standardized postpartum blood pressure control Aspirin 81 mg by mouth x 1 week post-delivery
No_intervention: Standard blood pressure control
Standardized postpartum blood pressure control
Related Therapeutic Areas
Sponsors
Collaborators: University of California, Irvine
Leads: MemorialCare Health System