Treatment With Aspirin After Preeclampsia: TAP Trial

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY

The objective of this research project is to conduct a single-site pilot trial to assess the feasibility and effect of low-dose aspirin to augment vascular recovery in the immediate postpartum period after preeclampsia through two specific aims: 1) to pilot test the feasibility of conducting a randomized controlled trial of postpartum low dose aspirin vs. placebo, and 2) to assess the effect of postpartum aspirin on endothelial function and blood pressure. Our central hypothesis is that postpartum administration of low-dose aspirin following preeclampsia will be feasible, improve endothelial function, and lower BP at 6 months postpartum. Subjects will undergo 3 study visits involving BP measurements, blood draws, questionnaires, and/or microiontophoresis. Up to 60 adult subjects will be enrolled at Magee-Women's Hospital.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 55
Healthy Volunteers: f
View:

• Postpartum individuals ≥18 years old

• Preeclampsia diagnosis

Locations
United States
Pennsylvania
University of Pittsburgh Magee-Womens Hospital
RECRUITING
Pittsburgh
Contact Information
Primary
Alisse K Hauspurg, MD
janickia@upmc.edu
412-641-1381
Backup
Sila Yavan, MS
yavans@upmc.edu
4124174981
Time Frame
Start Date: 2024-05-29
Estimated Completion Date: 2027-06-01
Participants
Target number of participants: 60
Treatments
Placebo_comparator: Placebo Group
Similar appearing placebo pill daily for 6 months will be given to subjects.
Experimental: Intervention Group
Low-dose \[81 mg\] aspirin pill daily for 6 months will be given to subjects
Related Therapeutic Areas
Sponsors
Leads: Alisse Hauspurg
Collaborators: National Heart, Lung, and Blood Institute (NHLBI)

This content was sourced from clinicaltrials.gov