Changes in the Lipidomic, Immunological and Circulating microRNA Profile in Patients With Hepatobiliary Pathology, Suffering From Morbid Obesity Undergoing a Dietary Program or Bariatric Surgery

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY

Obesity is a chronic disease characterized phenotypically by an increase in body weight (BMI\>30 kg/m2) and by a series of associated pathologies, such as hypertension, diabetes, hepatic steatosis. The association of these pathologies compromises the patient's survival and quality of life. The multifactorial origin of obesity makes its etiopathology difficult to manage. It is often possible to follow only one therapeutic strategy, especially after the so-called standard treatments, such as dietary intervention and physical activity, have not brought benefit to the patient. In these cases, an appropriate treatment for the patient to enjoy significant weight loss is bariatric surgery. Bariatric surgery refers to all those interventions aimed at reducing weight in those suffering from obesity, and treating the diseases associated with it. Among the different types of bariatric surgery, the techniques most used in common clinical practice are intragastric balloons, gastric by pass (RYGB) and sleeve gastrectomy. The choice of the surgeon, assisted by the multidisciplinary team, is binding in the choice of the type of operation to which the patient will be subjected.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Obese patients (BMI \>30kg/m2) suffering from hepato-biliary pathology diagnosed by Fibroscan

• Adult patients (\>18 years).

Locations
Other Locations
Italy
IRCCS Saverio de Bellis
RECRUITING
Castellana Grotte
Contact Information
Primary
Rossella Donghia, Biologyst
rossella.donghia@irccsdebellis.it
0804994652
Time Frame
Start Date: 2024-06-01
Estimated Completion Date: 2026-06-01
Participants
Target number of participants: 60
Treatments
Control group - Nutritional Approach
Patients who, after a multidisciplinary visit, are found to be ineligible for bariatric surgery.
Case group - Surgery Approach
Patients who, after a multidisciplinary visit, are referred for bariatric surgery.
Related Therapeutic Areas
Sponsors
Collaborators: Cozzolongo Raffaele, Shahini Endrit, Notarnicola Maria, Lippolis Giuseppe, De Pergola Giovanni
Leads: Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis

This content was sourced from clinicaltrials.gov