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Vagal Autonomic Stimulation Physiotherapy (With Trigger Point Release) as an Adjunct to Personalized Antihypertensive Management of Gestational Hypertension Syndrome and Preeclampsia

Status: Recruiting
Location: See all (4) locations...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Preeclampsia is one of the most common and serious complications of pregnancy, affecting both the mother and baby. It is a condition characterized by high blood pressure and can lead to severe complications, including neurological issues and reduced blood flow to the placenta. Preeclampsia is responsible for a significant number of maternal and perinatal deaths worldwide, with an estimated 14% of maternal mortality in Mexico linked to this condition. Recent research suggests that disruptions in the body's autonomic nervous system, specifically the balance between the sympathetic and parasympathetic systems, play a role in the development of preeclampsia. The vagus nerve, which is part of the parasympathetic system, has been shown to regulate inflammation and blood pressure. Stimulating this nerve through pharmacological, magnetic, electrical, or physical therapy techniques has shown promise in preclinical models for improving blood pressure control and reducing complications associated with preeclampsia. Trigger point release therapy modulates the nervous system by reducing sympathetic activity, promoting blood vessel relaxation, lowering heart rate, and enhancing circulation. When combined with standard antihypertensive treatment, this approach may offer additional benefits for blood pressure regulation. This study aims to evaluate the effects of vagal autonomic stimulation physiotherapy using trigger point release therapy as a complementary treatment for pregnant women with preeclampsia. Participants will be randomly assigned to receive either standard antihypertensive treatment with positional release therapy (control group) or the same treatment combined with vagal stimulation physiotherapy (intervention group). Researchers will assess the intervention's effectiveness in controlling blood pressure and improving overall maternal and fetal health outcomes. By investigating this non-invasive, drug-free approach, this study aims to offer new strategies for managing preeclampsia, potentially improving maternal and fetal health while reducing reliance on medication.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Healthy Volunteers: f
View:

• Outpatient female patients over 18 years old, attending their first appointment and seen in the obstetrics outpatient clinic at the Regional General Hospitals of IMSS Jalisco, with a pregnancy complicated by confirmed mild preeclampsia.

• No prior treatment.

• Willing to participate by signing an informed consent form.

Locations
Other Locations
Mexico
Hospital General de Zona 110, IMSS
RECRUITING
Guadalajara
Hospital General de Zona 46, IMSS
NOT_YET_RECRUITING
Guadalajara
Unidad de Investigación Biomédica 02, UMAE HE CMNO IMSS
NOT_YET_RECRUITING
Guadalajara
Hospital General de Zona 180, IMSS
NOT_YET_RECRUITING
Tlajomulco De Zúñiga
Time Frame
Start Date: 2026-04-15
Estimated Completion Date: 2027-06-01
Participants
Target number of participants: 210
Treatments
Experimental: Vagal Stimulation Physiotherapy with Trigger Point Release (TEV Group).
Administration of physiotherapy sessions for vagal stimulation with trigger point release, in addition to personalized antihypertensive treatment.
Active_comparator: Positional Release Therapy (TLP Group).
Administration of positional release therapy sessions, in addition to personalized antihypertensive treatment.
Related Therapeutic Areas
Sponsors
Collaborators: Coordinación de Investigación en Salud, Mexico
Leads: Fundación Internacional René Mey

This content was sourced from clinicaltrials.gov

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