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Hepatic Venous Pressure Gradient Versus Endoscopic Ultrasound-Guided Portal Pressure Gradient - Comparative Analysis

Status: Recruiting
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this interventional trial is to compare in measuring of portal hypertension by HVPG and EUS-PPG in subject indicated to HVPG measurement. The primary question is whether EUS-PPG provides measurements really equivalent to HVPG in terms of gradient accuracy. Participants undergoing HVPG will first undergo the procedure while conscious, performed by the first operator. Immediately thereafter, HVPG will be repeated following the induction of anesthesia by a second operator blinded to the initial readings. Subsequently, EUS-PPG will be performed by an endoscopist, who will also be blinded to all previous pressure measurements.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: f
View:

• Age 18-75 years at the time of enrollment; signed informed consent

• Clinical indication for HVPG measurement and/or transjugular liver biopsy for chronic advanced liver disease

Contact Information
Primary
Petr Hříbek, MD, PhD
petr.hribek@uvn.cz
+420973203065
Backup
Petr Urbánek, Prof.
petr.urbanek@uvn.cz
Time Frame
Start Date: 2025-05-30
Estimated Completion Date: 2028-12-31
Participants
Target number of participants: 40
Treatments
Experimental: Participants
Participants undergoing HVPG will first undergo the procedure while conscious, performed by the first operator. Immediately thereafter, HVPG will be repeated following the induction of anesthesia by a second operator blinded to the initial readings. Subsequently, EUS-PPG will be performed by an endoscopist, who will also be blinded to all previous pressure measurements.
Sponsors
Collaborators: University Hospital Prague (IKEM), Prague, Czech Republic
Leads: Military University Hospital, Prague

This content was sourced from clinicaltrials.gov