Feasibility and Efficacy of Transcutaneous Auricular Vagus Nerve Stimulation for Insomnia in Survivors of Childhood Acute Lymphoblastic Leukemia
Objective: Aim 1: To determine a) short-term and b) long-term feasibility of tVNS in terms of participation in ALL Survivors with moderate to severe insomnia. Aim 2: To estimate the effect size of tVNS on sleep quality, stress, and neurocognitive outcomes in ALL survivors with insomnia. Exploratory Objectives Aim 1: To investigate the onset of tVNS effect via actigraphy measures over the intervention epoch. Aim 2: To estimate the effect size of genetic variants on sleep quality within verum tVNS.
• Survivor of Acute Lymphoblastic Leukemia (ALL)
• Enrolled on SJLIFE
• Participant was less than 21 years of age at time of diagnosis.
• Age 20-50 years at the time of enrollment
• Insomnia Severity Index \>=8 (Proxy \>=8) confirmed prior to enrollment
• Access to home Wi-Fi and Smartphone
• Participant is able to speak and understand the English language
• Participant is able and willing to give consent