Learn About Acute Lymphoblastic Leukemia (ALL)

What is the definition of Acute Lymphoblastic Leukemia (ALL)?

Acute lymphoblastic leukemia (ALL) is a fast-growing cancer of a type of white blood cell called a lymphoblast.

ALL occurs when the bone marrow produces a large number of immature lymphoblasts. Bone marrow is the soft tissue in the center of bones that helps form all blood cells. The abnormal lymphoblasts grow quickly and replace normal cells in the bone marrow. ALL prevents healthy blood cells from being made. Life-threatening symptoms can occur as normal blood counts drop.

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What are the alternative names for Acute Lymphoblastic Leukemia (ALL)?

ALL; Acute lymphoblastic leukemia; Acute lymphoid leukemia; Acute childhood leukemia; Cancer - acute childhood leukemia (ALL); Leukemia - acute childhood (ALL); Acute lymphocytic leukemia

What are the causes of Acute Lymphoblastic Leukemia (ALL)?

Most of the time, no clear cause can be found for ALL.

The following factors may play a role in the development of all types of leukemia:

  • Certain chromosome problems
  • Exposure to radiation, including x-rays before birth
  • Past treatment with chemotherapy drugs
  • Receiving a bone marrow transplant
  • Toxins, such as benzene

The following factors are known to increase the risk for ALL:

  • Down syndrome or other genetic disorders
  • A brother or sister with leukemia

This type of leukemia usually affects children ages 3 to 7. ALL is the most common childhood cancer, but it can also occur in adults.

What are the symptoms of Acute Lymphoblastic Leukemia (ALL)?

ALL makes a person more likely to bleed and develop infections. Symptoms include:

  • Bone and joint pain
  • Easy bruising and bleeding (such as bleeding gums, skin bleeding, nosebleeds, abnormal periods)
  • Feeling weak or tired
  • Fever
  • Loss of appetite and weight loss
  • Paleness
  • Pain or feeling of fullness below the ribs from an enlarged liver or spleen
  • Pinpoint red spots on the skin (petechiae)
  • Swollen lymph nodes in the neck, under arms, and groin
  • Night sweats

These symptoms can occur with other conditions. Talk to a health care provider about the meaning of specific symptoms.

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What are the current treatments for Acute Lymphoblastic Leukemia (ALL)?

The first goal of treatment is to get blood counts back to normal. If this occurs and the bone marrow looks healthy under the microscope, the cancer is said to be in remission.

Chemotherapy is the first treatment tried with the goal of achieving a remission.

  • The person may need to stay in the hospital for chemotherapy. Or it can be given at a clinic and the person goes home afterward.
  • Chemotherapy is given into the veins (by IV) and sometimes into the fluid around the brain (the spinal fluid).

After a remission is achieved, more treatment is given to achieve a cure. This treatment can include more IV chemotherapy or radiation to the brain. Stem cell or, bone marrow, transplant from another person may also be done. Further treatment depends on:

  • Age and health of the person
  • Genetic changes in the leukemia cells
  • How many courses of chemotherapy it took to achieve remission
  • If abnormal cells are still detected under the microscope
  • Availability of donors for stem cell transplant

You and your provider may need to manage other concerns during your leukemia treatment, including:

  • Having chemotherapy at home
  • Managing your pets during chemotherapy
  • Bleeding problems
  • Dry mouth
  • Eating enough calories
  • Safe eating during cancer treatment
Who are the top Acute Lymphoblastic Leukemia (ALL) Local Doctors?
Elite
Highly rated in
36
conditions
Oncology
Hematology Oncology
Hematology

University of Texas System

Physicians Referral Service

1515 Holcombe Blvd, 
Houston, TX 

Tapan Kadia is an Oncologist and a Hematologist Oncology expert in Houston, Texas. Kadia has been practicing medicine for over 21 years and is rated as an Elite expert by MediFind in the treatment of Acute Lymphoblastic Leukemia ALL. He is also highly rated in 36 other conditions, according to our data. His top areas of expertise are Acute Myeloid Leukemia, Myelodysplastic Syndrome MDS, Leukemia, and Acute Lymphoblastic Leukemia ALL. He is licensed to treat patients in Texas. Kadia is currently accepting new patients.

Elite
Highly rated in
6
conditions
Pediatrics
Pediatric Hematology Oncology

Intermountain Healthcare

160 E 32nd St, 
New York, NY 

Elizabeth Raetz is a Pediatrics specialist and a Pediatric Hematologist Oncology expert in New York, New York. Raetz has been practicing medicine for over 30 years and is rated as an Elite expert by MediFind in the treatment of Acute Lymphoblastic Leukemia ALL. She is also highly rated in 6 other conditions, according to our data. Her top areas of expertise are Acute Lymphoblastic Leukemia ALL, Leukemia, Adult T-Cell Leukemia, and Infantile Neutropenia. She is licensed to treat patients in New York. Raetz is currently accepting new patients.

 
 
 
 
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Elite
Highly rated in
41
conditions
Hematology

Cedars-Sinai Health System

Duarte

1500 E Duarte Rd, 
Duarte, CA 

Stephen Forman is a Hematologist in Duarte, California. Forman has been practicing medicine for over 48 years and is rated as an Elite expert by MediFind in the treatment of Acute Lymphoblastic Leukemia ALL. He is also highly rated in 41 other conditions, according to our data. His top areas of expertise are Acute Myeloid Leukemia, Graft Versus Host Disease, Non-Hodgkin Lymphoma, and Acute Lymphoblastic Leukemia ALL. He is licensed to treat patients in California.

What are the support groups for Acute Lymphoblastic Leukemia (ALL)?

You can ease the stress of illness by joining a cancer support group. Sharing with others who have common experiences and problems can help you not feel alone.

What is the outlook (prognosis) for Acute Lymphoblastic Leukemia (ALL)?

Those who respond to treatment right away tend to do better. Most children with ALL can be cured. Children often have a better outcome than adults.

What are the possible complications of Acute Lymphoblastic Leukemia (ALL)?

Both leukemia itself and the treatment can lead to many problems such as bleeding, weight loss, and infections.

When should I contact a medical professional for Acute Lymphoblastic Leukemia (ALL)?

Call your provider if you or your child develops symptoms of ALL.

How do I prevent Acute Lymphoblastic Leukemia (ALL)?

The risk of developing ALL may be reduced by avoiding contact with certain toxins, radiation, and chemicals.

Bone marrow aspiration
Acute lymphocytic leukemia - photomicrograph
Auer rods
Bone marrow from hip
Immune system structures
What are the latest Acute Lymphoblastic Leukemia (ALL) Clinical Trials?
A Feasibility Study Following a Phase 2a Design to Demonstrate Successful Local Manufacture of Chimeric Antigen Receptor (CAR) T-Cell Products for the Treatment of B-Cell Lymphoma and B-Acute Lymphoblastic Leukemia
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Phase 1/2 Trial of TC-110 T Cells in Adults With Relapsed or Refractory Non-Hodgkin Lymphoma (NHL) or Acute Lymphoblastic Leukemia (ALL)
What are the Latest Advances for Acute Lymphoblastic Leukemia (ALL)?
Case report: Successful allogeneic stem cell transplantation in a child with novel GATA2 defect associated B-cell acute lymphoblastic leukemia.
Clinical study of mesenchymal stem cells from third-party donors in the treatment of refractory late onset hemorrhagic cystitis after allogeneic hematopoietic stem cell transplanation.
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Donor-Derived CD7 CAR-T Therapy Followed by Allogeneic Hematopoietic Stem Cell Transplantation for Acute T-Lymphocytic Leukemia Associated With Hepatitis B: A Case Report.
Who are the sources who wrote this article ?

Published Date: February 06, 2020
Published By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Internal review and update on 06/03/2021 by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

What are the references for this article ?

Carroll WL, Bhatla T. Acute lymphoblastic leukemia. In: Lanzkowsky P, Lipton JM, Fish JD, eds. Lanzkowsky's Manual of Pediatric Hematology and Oncology. 6th ed. Cambridge, MA: Elsevier Academic Press; 2016:chap 18.

National Cancer Institute website. Adult acute lymphoblastic leukemia treatment (PDQ) - health professional version. www.cancer.gov/types/leukemia/hp/adult-all-treatment-pdq. Updated January 31, 2021. Accessed June 3, 2021.

National Cancer Institute website. Childhood acute lymphoblastic leukemia treatment (PDQ) - health professional version. www.cancer.gov/types/leukemia/hp/child-all-treatment-pdq. Updated February 4, 2021. Accessed June 3, 2021.