Acute lymphoblastic leukemia (ALL) is a fast-growing cancer of a type of white blood cell called a lymphoblast.
ALL occurs when the bone marrow produces a large number of immature lymphoblasts. Bone marrow is the soft tissue in the center of bones that helps form all blood cells. The abnormal lymphoblasts grow quickly and replace normal cells in the bone marrow. ALL prevents healthy blood cells from being made. Life-threatening symptoms can occur as normal blood counts drop.
ALL; Acute lymphoblastic leukemia; Acute lymphoid leukemia; Acute childhood leukemia; Cancer - acute childhood leukemia (ALL); Leukemia - acute childhood (ALL); Acute lymphocytic leukemia
Most of the time, no clear cause can be found for ALL.
The following factors may play a role in the development of all types of leukemia:
The following factors are known to increase the risk for ALL:
This type of leukemia usually affects children ages 3 to 7. ALL is the most common childhood cancer, but it can also occur in adults.
ALL makes a person more likely to bleed and develop infections. Symptoms include:
These symptoms can occur with other conditions. Talk to a health care provider about the meaning of specific symptoms.
The first goal of treatment is to get blood counts back to normal. If this occurs and the bone marrow looks healthy under the microscope, the cancer is said to be in remission.
Chemotherapy is the first treatment tried with the goal of achieving a remission.
After a remission is achieved, more treatment is given to achieve a cure. This treatment can include more IV chemotherapy or radiation to the brain. Stem cell or, bone marrow, transplant from another person may also be done. Further treatment depends on:
You and your provider may need to manage other concerns during your leukemia treatment, including:
Tapan Kadia is an Oncologist and a Hematologist Oncology expert in Houston, Texas. Kadia has been practicing medicine for over 21 years and is rated as an Elite expert by MediFind in the treatment of Acute Lymphoblastic Leukemia ALL. He is also highly rated in 36 other conditions, according to our data. His top areas of expertise are Acute Myeloid Leukemia, Myelodysplastic Syndrome MDS, Leukemia, and Acute Lymphoblastic Leukemia ALL. He is licensed to treat patients in Texas. Kadia is currently accepting new patients.
Elizabeth Raetz is a Pediatrics specialist and a Pediatric Hematologist Oncology expert in New York, New York. Raetz has been practicing medicine for over 30 years and is rated as an Elite expert by MediFind in the treatment of Acute Lymphoblastic Leukemia ALL. She is also highly rated in 6 other conditions, according to our data. Her top areas of expertise are Acute Lymphoblastic Leukemia ALL, Leukemia, Adult T-Cell Leukemia, and Infantile Neutropenia. She is licensed to treat patients in New York. Raetz is currently accepting new patients.
Stephen Forman is a Hematologist in Duarte, California. Forman has been practicing medicine for over 48 years and is rated as an Elite expert by MediFind in the treatment of Acute Lymphoblastic Leukemia ALL. He is also highly rated in 41 other conditions, according to our data. His top areas of expertise are Acute Myeloid Leukemia, Graft Versus Host Disease, Non-Hodgkin Lymphoma, and Acute Lymphoblastic Leukemia ALL. He is licensed to treat patients in California.
You can ease the stress of illness by joining a cancer support group. Sharing with others who have common experiences and problems can help you not feel alone.
Those who respond to treatment right away tend to do better. Most children with ALL can be cured. Children often have a better outcome than adults.
Both leukemia itself and the treatment can lead to many problems such as bleeding, weight loss, and infections.
Call your provider if you or your child develops symptoms of ALL.
The risk of developing ALL may be reduced by avoiding contact with certain toxins, radiation, and chemicals.
Published Date: February 06, 2020
Published By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Internal review and update on 06/03/2021 by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
Carroll WL, Bhatla T. Acute lymphoblastic leukemia. In: Lanzkowsky P, Lipton JM, Fish JD, eds. Lanzkowsky's Manual of Pediatric Hematology and Oncology. 6th ed. Cambridge, MA: Elsevier Academic Press; 2016:chap 18.
National Cancer Institute website. Adult acute lymphoblastic leukemia treatment (PDQ) - health professional version. www.cancer.gov/types/leukemia/hp/adult-all-treatment-pdq. Updated January 31, 2021. Accessed June 3, 2021.
National Cancer Institute website. Childhood acute lymphoblastic leukemia treatment (PDQ) - health professional version. www.cancer.gov/types/leukemia/hp/child-all-treatment-pdq. Updated February 4, 2021. Accessed June 3, 2021.