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Virtual Walking With Habitual Feedback to Reduce Chronic Neuropathic Pain in Individuals With Spinal Cord Injury

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

About 70% of people with a spinal cord injury in Switzerland have chronic pain that lasts more than 3 to 6 months. This pain can be caused by muscle or joint problems, or by nerve damage (neuropathic pain). Neuropathic pain is often hard to treat, and current treatments may cause side effects or not work well. This study will test whether virtual walking from different visual perspectives can reduce chronic neuropathic pain and improve quality of life after spinal cord injury. We will also compare which perspective works best. To better understand how the training works, we will use two tests-quantitative sensory testing (QST) and contact heat-evoked potentials (CHEPs)-to measure changes in the pain and nerve systems.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: f
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• Sufficient knowledge of German language to understand the instructions, assessments and to fill in questionnaires.

• Age ≥ 18y, ≤ 75y

• Chronic traumatic or non-traumatic SCI (\>6 month after SCI) with an SCI severity grade AIS A, B, C or D

• At or below level spinal cord injury neuropathic pain on trunk or lower extremities diagnosed by a neurologist following the ISCIP classification (Bryce et al., 2012) of at least 4/10 intensity on a NRS (Langford et al., 2023)

• Ability to draw with a pen

Locations
Other Locations
Switzerland
Schweizer Paraplegiker Zentrum Nottwil
RECRUITING
Nottwil
Contact Information
Primary
Karina Ottiger, MAS
karina.ottiger@paraplegie.ch
+41419394900
Backup
Gunther Landmann, KD Dr. med.
gunther.landmann@paraplegie.ch
+41419394900
Time Frame
Start Date: 2026-01-20
Estimated Completion Date: 2027-11-30
Participants
Target number of participants: 40
Treatments
Experimental: Group 1
Participants will receive virtual walking (VW) therapy with a personalized avatar. Using a green screen setup, a live video of the participant's upper body is combined with pre-recorded walking legs to create a full-body walking illusion, displayed on a large projection screen in a forest environment. The participant will be seated in a modified wheelchair that tilts 2° to each side to simulate pelvic movement during walking.
Sham_comparator: Group 2
Participants will receive virtual walking (VW) therapy without an avatar. The screen will display only a moving forest environment, and the wheelchair tilt will be omitted. This condition serves as a sham intervention, matching Group 1 in session number, duration, and procedure, but without the visual and vestibular walking components.
No_intervention: Control Group
Participants will receive standard medical pain management only. They will not take part in virtual walking therapy but will complete the pain diary and questionnaires at the scheduled assessment time points.
Related Therapeutic Areas
Sponsors
Leads: Swiss Paraplegic Research, Nottwil

This content was sourced from clinicaltrials.gov