Influenza-associated Pulmonary Aspergillosis (IAPA) in ICU Patients With Severe Influenza: Incidence and Host- and Pathogen Related Risk Factors
Status: Recruiting
Location: See all (12) locations...
Intervention Type: Other
Study Type: Observational
SUMMARY
A prospective multi-center observational study to assess the incidence of influenza-associated pulmonary aspergillosis (IAPA) in ICU patients and to identify host- and pathogen related risk factors for IAPA in EORTC negative ICU patients with severe influenza.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Patients with a PCR-positive respiratory virus panel (RVP) result for influenza within 96 hours before or 48 hours after ICU admission.
• Patients who require ICU admission for more than 24 hours for severe influenza.
• Patients who have respiratory distress (respiratory rate \>= 25x/minute and paO2/fiO2 \< 300 with or without bilateral infiltrates) as the main reason for ICU admission.
• Patients who do not have an EORTC host factor.
• Patients who are at least 18 years of age.
Locations
Other Locations
Belgium
AZ St-Jan
RECRUITING
Bruges
UZ Leuven
RECRUITING
Leuven
AZ Delta
RECRUITING
Roeselare
France
Amiens-Picardie University Hospital
RECRUITING
Amiens
Centre Hospitalier REgional Universitaire de Lille
RECRUITING
Lille
Henri Mondor Hopital
RECRUITING
Paris
Hopital Bichat
RECRUITING
Paris
Hopital Lariboisiere
RECRUITING
Paris
Hopital Pontchaillou, Centre Hospitalier Universitaire de Rennes
RECRUITING
Rennes
Netherlands
AmsterdamUMC, locatie VUmc
RECRUITING
Amsterdam
Universitair Medisch Centrum Groningen
RECRUITING
Groningen
Radboudumc
RECRUITING
Nijmegen
Contact Information
Primary
Joost Wauters, MD, PhD
joost.wauters@uzleuven.be
+32-16-344275
Time Frame
Start Date: 2022-03-10
Estimated Completion Date: 2026-06-30
Participants
Target number of participants: 350
Treatments
IAPA+
Influenza patients who develop IAPA during ICU admission
IAPA-
Influenza patients admitted to the ICU not developing IAPA
Related Therapeutic Areas
Sponsors
Leads: Radboud University Medical Center