Diesel Exhaust Induces Glucocorticoid Resistance

Who is this study for? Patients with asthma
What treatments are being studied? Budesonide+Diesel Exhaust
Status: Recruiting
Location: See location...
Intervention Type: Other, Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY

The investigators are studying the effects of exposure to diesel exhaust on lung inflammation in the presence and absence of an inhaled corticosteroid. Although data is mixed, studies show that asthmatics have increased lung inflammation and worse symptoms during periods of higher air pollution despite taking their anti-inflammatory corticosteroid medication. One possible reason is that air pollution exposure may decrease the ability of corticosteroids to combat inflammation. To test this volunteers will inhale either a placebo or a corticosteroid, before sitting in an exposure booth for 2 hours breathing either filtered air or diluted diesel exhaust. Samples will be collected before and after exposure to analyze the effects of budesonide and diesel exhaust exposure.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 19
Maximum Age: 49
Healthy Volunteers: f
View:

• Aged 19-49

• Have physician-diagnosed asthma confirmed by the study physician examination, spirometry, methacholine challenge provocative concentration causing a 20% fall (PC20) of \<16 mg/mL, and questionnaires during a screening visit

Locations
Other Locations
Canada
University of British Columbia
RECRUITING
Vancouver
Contact Information
Primary
Parteek (PJ) Johal, BCS
de.study@ubc.ca
6048755132
Backup
Agnes CY Yuen, BSc
agnes.yuen@ubc.ca
6048754111
Time Frame
Start Date: 2018-12-01
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 30
Treatments
Placebo_comparator: Placebo and Filtered Air
Volunteers will use an inhaler that does not contain any medication, before sitting in a booth and being exposed to high-efficiency particulate air (HEPA) filtered air for 2 hours.
Active_comparator: Budesonide and Filtered Air
Volunteers will inhale 1.6mg of budesonide before sitting in a booth and being exposed to HEPA filtered air for 2 hours.
Active_comparator: Placebo and Diesel Exhaust
Volunteers will use an inhaler that does not contain any medication, before sitting in a booth and being exposed to 300µg/m³ concentration of diesel exhaust for 2 hours.
Experimental: Budesonide and Diesel Exhaust
Volunteers will inhale 1.6mg of budesonide before sitting in a booth and being exposed to 300µg/m³ concentration of diesel exhaust for 2 hours.
Related Therapeutic Areas
Sponsors
Collaborators: Canadian Institutes of Health Research (CIHR), AllerGen NCE Inc.
Leads: University of British Columbia

This content was sourced from clinicaltrials.gov