NeoDoppler: New Ultrasound Technology for Continuous Monitoring of Cerebral Blood Flow in Infants

Status: Recruiting

Location: See location...

Intervention Type: Device

Study Type: Observational

SUMMARY

Non-invasive tools for monitoring of course of disease are important and necessary in the treatment of pre-term/premature infants and sick neonates. For many years, the ultrasound group in Trondheim has been at the forefront in the development of new ultrasound technology for the diagnosis and monitoring of disease. Several methods previously developed in this research group are today widely used in hospitals around the world. In this project the investigators aim to test a new ultrasound technology that allows continuous monitoring of cerebral blood flow in sick neonates and pre-term children. This technology was CE-certified in October 2022, and in this project the investigators will test the CE-certified version with the newest available approved software.

Eligibility

Participation Requirements

Sex: All

Maximum Age: 1

Healthy Volunteers: t

View:

• Open fontanelle

• Healthy preterm or term born neonates

• Neonates with a medical condition of interest according to the different cohort studies: patent ductus arteriosus, perinatal asphyxia, stroke, pulmonary hypertension, congenital heart condition or infection/sepsis/meningitis

• Neonates in need of procedures

Locations

Other Locations

Norway

Children's clinic, St. Olavs University Hospital

RECRUITING

Trondheim

Contact Information

Primary

Siri Ann Nyrnes, MD, PhD

siri.a.nyrnes@ntnu.no

004793062121

Backup

Siv Steinsmo Ødegård, MD, PhD

siv.steinsmo@gmail.com

97772989

Time Frame

Start Date: 2024-10-20

Estimated Completion Date: 2029-12-31

Participants

Target number of participants: 180

Treatments

Feasibility study - Healthy neonates

Neonates born with gestational week \< 32 weeks, gestational week 32-37 and at term. Will will include 20-30 of each sex in each group.

Patients with patent ductus arteriosus (premature infants)

Preterm neonates with patent ductus arteriosus (n=20)

Different groups of sick neonates

Neonates with different medical conditions such as perinatal asphyxia, stroke, pulmonary hypertension and congenital heart disease will be conducted. We will include 5-30 neonates in each group.

Neonates/infants undergoing procedures

Neonates/infants undergoing procedures such as intubation, anesthesia, spinal puncture, peripheral and central arterial and venous catheter. We will include 20-30 neonates.

Neonates with infection/sepsis

Infants with infection/sepsis and/or meningitis (n=40).

Related Therapeutic Areas

Hypertension

Stroke

Pulmonary Hypertension

High Blood Pressure in Infants

Patent Ductus Arteriosus

Sepsis

Similar Clinical Trials

View All

NeoDoppler: New Ultrasound Technology for Continuous Monitoring of Cerebral Blood Flow in Infants

Similar Clinical Trials

Clinical Microbial Species and Antibiotic Resistance Identification in Patients Presenting to the Emergency Department With Three of Four Systemic Inflammatory Response Syndrome (SIRS) Criteria - is Rapid Identification Possible and Accurate?

Clinical Microbial Species and Antibiotic Resistance Identification in Patients Presenting to the Emergency Department With Three of Four Systemic Inflammatory Response Syndrome (SIRS) Criteria - is Rapid Identification Possible and Accurate?

Regular Intestinal Lavage to Promote Enteral Feeding and Prevent Necrotizing Enterocolitis in Extremely Preterm Infants. A Randomized Controlled Trial Protocol

Regular Intestinal Lavage to Promote Enteral Feeding and Prevent Necrotizing Enterocolitis in Extremely Preterm Infants. A Randomized Controlled Trial Protocol

Self-directed Mobile Adaptive Coping Skills Intervention to Improve Psychological Distress Symptoms Among Cardiorespiratory Failure Survivors: Blueprint 2

Self-directed Mobile Adaptive Coping Skills Intervention to Improve Psychological Distress Symptoms Among Cardiorespiratory Failure Survivors: Blueprint 2