Passive Limb Movement Study

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Stroke survivors have compromised vascular function which may contribute to secondary stroke risk, cardiovascular disease, and may limit their exercise tolerance. No studies have examined how femoral blood flow responds to both passive leg movement, a measure of microvascular function, as well as active leg contractions, a measure of the hyperemic response to exercise. Leg muscles with a reduced blood flow response to movement could be associated with decreased neuromuscular function, such as leg strength and fatigue. Preliminary data showing a single bout of ischemic conditioning may improve vascular function and muscle activation in healthy adults and individuals post-stroke. Therefore, the investigators want to examine if ischemic conditioning will also improve the blood flow response to passive leg movements as well as during single leg active contractions.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 85
Healthy Volunteers: t
View:

• Individuals Post-Stroke

‣ 18 - 85 years of age

⁃ Cortical or sub-cortical stroke ≥ 6 months ago with residual hemiparesis

⁃ Able to give informed consent and follow 2-step command.

⁃ English Speaking

• Age- and Sex-Matched Controls (CON)

‣ Matched to age of individual post- stroke ± 5 years.

⁃ Matched to sex of individual post-stroke

⁃ Able to give informed consent and follow 2-step command.

⁃ English Speaking

• Young Healthy Adults (CONyoung)

‣ Age 18-30 years old

⁃ Able to give informed consent and follow 2-step command.

⁃ English Speaking

Locations
United States
Wisconsin
Medical College of Wisconsin
RECRUITING
Milwaukee
Contact Information
Primary
Jennifer Nguyen
jnguyen@mcw.edu
414-955-5619
Backup
Alicen Whitaker-Hilbig, PhD
awhitakerhilbig@mcw.edu
Time Frame
Start Date: 2023-06-13
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 55
Treatments
Experimental: Ischemic Conditioning - High
During each testing session, the investigators will be measuring how one treatment of ischemic conditioning effects leg blood flow and muscle function. One day participants will receive a high cuff inflation pressure on the leg, called ischemic conditioning - high (225 mmHg).
Experimental: Ischemic Conditioning - Low
During each testing session, the investigators will be measuring how one treatment of ischemic conditioning effects leg blood flow and muscle function. One day participants will receive a low cuff inflation pressure on the leg, called ischemic conditioning - low (25 mmHg).
Related Therapeutic Areas
Sponsors
Leads: Medical College of Wisconsin
Collaborators: Marquette University

This content was sourced from clinicaltrials.gov