MitoQ and Ischemic Conditioning To Assess Vascular Health Outcomes (MITO Study)
Status: Recruiting
Location: See location...
Intervention Type: Dietary supplement, Device
Study Type: Interventional
Study Phase: Phase 2
SUMMARY
Stroke survivors have compromised vascular function which may contribute to secondary stroke risk, cardiovascular disease, and may limit their exercise tolerance. Preliminary data shows a single bout of ischemic conditioning or oral ingestion of an over-the-counter antioxidant supplement called MitoQ may improve vascular function and muscle activity in individuals post-stroke.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 85
Healthy Volunteers: f
View:
• 18 - 85 years of age
• Cortical or sub-cortical stroke ≥ 6 months ago with residual hemiparesis
• Able to give informed consent and follow 2-step command.
• English Speaking
Locations
United States
Wisconsin
Medical College of Wisconsin
RECRUITING
Milwaukee
Contact Information
Primary
Jennifer Nguyen
jnguyen@mcw.edu
414-955-5713
Backup
Alicen Whitaker-Hilbig, DPT, PhD
awhitakerhilbig@mcw.edu
414-955-5713
Time Frame
Start Date: 2025-07-22
Estimated Completion Date: 2026-12-31
Participants
Target number of participants: 30
Treatments
Experimental: Ischemic Conditioning - High
During each testing session, the investigators will be measuring how one treatment of ischemic conditioning affects blood flow and muscle function. One day participants will receive a high cuff inflation pressure on the leg, called ischemic conditioning - high (225 mmHg).
Experimental: Ischemic Conditioning - Low
During each testing session, the investigators will be measuring how one treatment of ischemic conditioning affects blood flow and muscle function. One day participants will receive a low cuff inflation pressure on the leg, called ischemic conditioning - low (25 mmHg).
Experimental: Antioxidant Supplement
During each testing session, the investigators will be measuring how one treatment of an over-the-counter antioxidant supplement affects blood flow and muscle function. One day participants will orally ingest an over-the-counter antioxidant supplement called MitoQ.
Related Therapeutic Areas
Sponsors
Leads: Medical College of Wisconsin