Understanding Motor Function in Stroke Patients and Their Functional Brain Reorganization Using Ultra High-field MRI (MOTF-STROKE)
The MOTIF-STROKE study is embedded within the BrainSync project, aiming to develop innovative strategies for motor rehabilitation of the upper limb. The primary goal is to construct a high-resolution anatomo-functional disconnection atlas in a cohort of 100 stroke patients, using cutting-edge 3T and 7T MRI. Data acquisition, commencing in Fall 2025, will combine morphological (T1-weighted), functional and diffusion-weighted MRI scans to perform morphometry, functional and structural connectivity analyses with biomarkers of motor deficits. This atlas seeks to correlate connectivity with motor tasks, using dedicated task-related fMRI paradigms and digital consultation tools. The project utilizes machine learning algorithms and functional hyper-alignment to analyze fMRI data, focusing on input features and their impact on prediction accuracy. The ultimate objective is to optimize implantation of WIMAGINE neuroprostheses for the subsequent BCI4STROKE clinical trial. Expected results include identifying clinical subgroups responsive to motor intention decoding, characterizing phenotypes of functional reorganization, and making the 3D brain atlas accessible to the neuroscience community.
⁃ Patients
• 1-MRI-confirmed diagnosis of a first ischemic stroke occurring more than 6 months prior to inclusion.
• 2-Persistent upper-limb motor deficit resulting from the stroke.
• 3-Absence of significant cognitive impairment: MMSE score ≥ 27 assessed as part of clinical care.
• 4-Age between 18 and 70 years.
• 5-Validation by the inclusion validation committee.
• 6-Signed informed consent after clear and fair information about the study.
⁃ Healthy volunteers:
• 1-Age between 18 and 70 years.
• 2-No history of neurological or psychiatric disease.
• 3-Signed informed consent after clear and fair information about the study.