Obstructive Sleep Apnea as a Remote Ischemic Preconditioning in Patients Scheduled for Aorto-bifemoral Bypass Surgery

Status: Recruiting
Intervention Type: Procedure
Study Type: Observational
SUMMARY

Ischemia and reperfusion (I/R) injury during abdominal aortic aneurysm (AAA) repair is inevitable and may lead to postoperative multi-organ failure. Remote ischemic preconditioning (short periods of ischemia in anticipation of longer period of ischemia) may act protectively against ischemia. Studies of ischemic preconditioning in patients with AAA are conflicting. Obstructive sleep apnea (OSA) is a sleep disordered breathing syndrome which may have a protective effect against ischemia. The investigators hypothesize that I/R injury will be less pronounced in patients who have OSA and that the extent of I/R injury will inversely correlate with OSA severity. Accordingly, the aim of this study is to compare postoperative complications and markers of I/R in patients undergoing elective AAA repair who do and do not have OSA.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• patients scheduled for elective aorto-bifemoral bypass (AAA and Leriche syndrome patients)

Contact Information
Primary
Ivan Cundrle, M.D., Ph.D.
ivan.cundrle@fnusa.cz
00420543182553
Backup
Marek Lukes, M.D.
marek.lukes@fnusa.cz
00420543182553
Time Frame
Start Date: 2020-11-01
Estimated Completion Date: 2026-01-31
Participants
Target number of participants: 100
Treatments
Obstructive Sleep Apnea
Pacient with OSA (AHI≥5) undergoing aorto-bifemoral bypass
Without Obstructive Sleep Apnea
Patinets without OSA undergoing aorto-bifemoral bypass
Sponsors
Collaborators: Masaryk University
Leads: St. Anne's University Hospital Brno, Czech Republic

This content was sourced from clinicaltrials.gov