Determining the Mechanisms of Loss of CAR T Cell Persistence
Status: Recruiting
Location: See all (3) locations...
Study Type: Observational
SUMMARY
A prospective observational study of pediatric and young adult acute lymphoblastic leukaemia (ALL) patients treated with CD19 chimeric antigen receptor T-cells (CAR-T cells). The study will examine changes in CAR-T persistence over time and causal factors.
Eligibility
Participation Requirements
Sex: All
Maximum Age: 25
Healthy Volunteers: f
View:
• Children and young adults (age 25 years or younger) with relapsed/refractory ALL who are planned to receive licensed CD19-targeted CAR-T cell treatment (Tisagenlecleucel)
• Written informed consent
Locations
Other Locations
United Kingdom
Great Ormond Street Hospital
RECRUITING
London
University College London Hospital
RECRUITING
London
Royal Manchester Children's Hospital
RECRUITING
Manchester
Contact Information
Primary
CARPERS Trial Manager
ctc.carpers@ucl.ac.uk
442031084189
Time Frame
Start Date: 2023-10-18
Estimated Completion Date: 2025-12-01
Participants
Target number of participants: 50
Related Therapeutic Areas
Sponsors
Leads: University College, London