Acute Monoblastic Leukemia (AmoL)
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Learn About Acute Monoblastic Leukemia (AmoL)

View Main Condition: Leukemia

What is the definition of Acute Monoblastic Leukemia (AmoL)?
Acute monoblastic leukemia (AML-M5), is one of the most common subtypes of acute myeloid leukemia (AML; see this term) that is either comprised of more than 80% of monoblasts (AML-M5a) or 30-80% monoblasts with (pro)monocytic differentiation (AML-M5b). AML-M5 presents with asthenia, pallor, fever, and dizziness. Specific features of AML-M5 include hyperleukocytosis, propensity for extramedullary infiltrates, coagulation abnormalities including disseminated intravascular coagulation and neurological disorders. Leukemia cutis and gingival infiltration can also be seen. A characteristic translocation observed in AML-M5 is t(9;11).
What are the alternative names for Acute Monoblastic Leukemia (AmoL)?
  • Acute monoblastic leukemia
  • AML M5
  • AML-M5
  • Acute monocytic leukemia
  • Acute myeloblastic leukemia type 5
Who are the top Acute Monoblastic Leukemia (AmoL) Local Doctors?
Elite in Acute Monoblastic Leukemia (AmoL)
Elite in Acute Monoblastic Leukemia (AmoL)

Montefiore Medical Center

111 East 210th Street, 
Bronx, NY 
Languages Spoken:
English
Offers Telehealth

Marina Konopleva, MD, Phd, is Professor, Oncology, Professor, Molecular Pharmacology, Director, Leukemia Program and Co-Director, Blood Cancer Institute, at Montefiore Einstein. Her clinic focus centers on treating patients with hematologic malignancies, with an emphasis on acute myeloid and acute lymphoblastic leukemia. She has additional expertise in treating patients with high-risk myelodysplastic syndrome and chronic myeloid leukemia. Dr. Konopleva is rated as an Elite provider by MediFind in the treatment of Acute Monoblastic Leukemia (AmoL). She is also highly rated in 25 other conditions, according to our data. Her clinical expertise encompasses Acute Myeloid Leukemia (AML), Leukemia, Myelodysplastic Syndrome (MDS), Bone Marrow Aspiration, and Bone Marrow Transplant.

Elite in Acute Monoblastic Leukemia (AmoL)
Elite in Acute Monoblastic Leukemia (AmoL)

University Of Colorado Hospital

12605 E 16th Ave, 
Aurora, CO 
Languages Spoken:
English
Offers Telehealth

Daniel Pollyea is a Hematologist practicing medicine in Aurora, Colorado. Dr. Pollyea is rated as an Elite provider by MediFind in the treatment of Acute Monoblastic Leukemia (AmoL). He is also highly rated in 22 other conditions, according to our data. His clinical expertise encompasses Acute Myeloid Leukemia (AML), Leukemia, Acute Monoblastic Leukemia (AmoL), Bone Marrow Aspiration, and Bone Marrow Transplant.

 
 
 
 
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Elite in Acute Monoblastic Leukemia (AmoL)
Elite in Acute Monoblastic Leukemia (AmoL)
157 Xiwu Road, 
Xi'an, CN 

Wanggang Zhang practices practicing medicine in Xi'an, China. Zhang is rated as an Elite expert by MediFind in the treatment of Acute Monoblastic Leukemia (AmoL). They are also highly rated in 3 other conditions, according to our data. Their clinical expertise encompasses Acute Monoblastic Leukemia (AmoL), Leukemia, Acute Myeloid Leukemia (AML), and Multiple Myeloma.

What are the latest Acute Monoblastic Leukemia (AmoL) Clinical Trials?
A Phase II Study of Venetoclax (ABT-199) in Combination With Cladribine and Low-Dose Cytarabine Alternating With Azacitidine Plus Venetoclax in Newly Diagnosed Monocytic AML and Active-Signaling Mutated AML

Summary: This phase II trial tests how well venetoclax with cladribine and cytarabine alternating with azacitidine and venetoclax works in treating patients with newly diagnosed monocytic acute myeloid leukemia (AML) and active signaling mutated AML. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking BCL-2, a protein neede...

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Venetoclax Combined With CACAG Regimen Versus 3+7 Regimen in the Treatment of Acute Monocytic Leukemia: A Prospective, Randomized, Controlled Study

Summary: This study is a multicenter, randomized, prospective Phase II clinical trial designed to compare the effectiveness of two treatment approaches for patients with acute monocytic leukemia.

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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center