Learn About Acute Promyelocytic Leukemia

View Main Condition: Leukemia

What is the definition of Acute Promyelocytic Leukemia?
Acute promyelocytic leukemia (APL) is an aggressive type of acute myeloid leukemia in which there are too many immature blood-forming cells (promyelocytes) in the blood and bone marrow. This build up of promyelocytes leads to a shortage of normal white and red blood cells and platelets in the body. The signs and symptoms of APL include an increased risk to both bleed and form blood clots. Individuals may also experience excessive tiredness, pain in affected areas, loss of appetite, and weight loss. It is caused by a genetic change that is acquired over a person's lifetime, usually involving a translocation between chromosomes 15 and 17.
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What are the alternative names for Acute Promyelocytic Leukemia?
  • Acute promyelocytic leukemia
  • AML M3
  • AML with t(15;17)(q22;q12);(PML/RARalpha) and variants
  • APML
  • Acute myeloblastic leukemia 3
  • Acute myeloblastic leukemia type 3
  • Acute myeloid leukemia with t(15;17)(q22;q12);(PML/RARalpha) and variants
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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center

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