Early Use of Airway Pressure Release Ventilation (APRV) in Patients With Acute Respiratory Distress Syndrome
Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
Airway pressure release ventilation (APRV) is a time-cycled, pressure controlled, intermittent mandatory ventilation mode with extreme inverse I:E ratios. Currently it is considered as a non-conventional ventilatory mode. The investigators aim to compare APRV with conventional mechanical ventilation (MV) in patients with acute respiratory distress syndrome (ARDS).
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: f
View:
• Acute respiratory distress syndrome, according to the Berlin definition of ARDS, with adjusted pO2/FiO2 for altitude \<300, and less than 48 h of endotracheal mechanical ventilation
Locations
Other Locations
Mexico
Hospital Civil Fray Antonio Alcalde
RECRUITING
Guadalajara
Contact Information
Primary
Miguel Ibarra-Estrada, Dr
drmiguelibarra@hotmail.com
3317593502
Backup
Guadalupe Aguirre-Avalos, Dr
guadalupe.aavalos@academicos.udg.mx
Time Frame
Start Date: 2017-07-15
Estimated Completion Date: 2026-01
Participants
Target number of participants: 150
Treatments
Active_comparator: Conventional ventilation
Protective lung conventional strategy with volume-controlled ventilation (VCV) or pressure-controlled ventilation (PCV) mode, with low tidal volume and adequate positive end expiratory pressure (PEEP) level.
Experimental: Time-controlled adaptive APRV
Airway Pressure Release Ventilation with Time-controlled adaptive ventilation method. Allowing for spontaneous breathing.
Related Therapeutic Areas
Sponsors
Leads: Hospital Civil de Guadalajara