Effects of Low Tidal Volume and Airway Pressure Release Ventilation on Lung Tissue Mechanics in ARDS Patients Under Mechanical Ventilation: A Prospective Randomized Crossover Study
Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The goal of this clinical trial is to learn how low tidal volume ventilation (LTV) and airway pressure release ventilation (APRV) affect lung tissue mechanics in adults with ARDS. The main questions it aims to answer are: Does LTV or APRV improve lung tissue mechanics in patients with ARDS under mechanical ventilation? Researchers will compare LTV and APRV to see which ventilation mode works better for improving lung mechanics and patient safety.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: f
View:
• Meets the diagnostic criteria of the 2023 Global New Definition of ARDS.
• Age: 18-80 years.
• PaO2/FiO2 ≤ 200.
• Within 12 hours of invasive mechanical ventilation treatment.
• Obtain consent from the patient or their family members to participate in the study, and sign the informed consent form.
Locations
Other Locations
China
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
RECRUITING
Wuhan
Contact Information
Primary
Xiaojing Zou Professor
13995518630@163.com
13995518630
Time Frame
Start Date: 2024-11-20
Estimated Completion Date: 2025-11-20
Participants
Target number of participants: 15
Treatments
Experimental: Intervention group
Airway Pressure Release Ventilation (APRV)
No_intervention: Control group
Low tidal volume ventilation
Related Therapeutic Areas
Sponsors
Leads: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology