Adult T-Cell Leukemia
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Adult T-Cell Leukemia Overview

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Learn About Adult T-Cell Leukemia

View Main Condition: Leukemia

What is the definition of Adult T-Cell Leukemia?
Adult T-cell leukemia/lymphoma (ATL) is is a rare and aggressive T-cell lymphoma that is linked to infection by the human T-cell lymphotropic virus 1 (HTLV-1). The exact mechanism by which HTLV-I infection causes the ATL is unknown. The clinical features of ATL include generalized swelling of the lymph nodes (lymphadenopathy), increased liver and spleen size (hepatosplenomegaly), immunosuppression, high levels of calcium in the blood, lytic bone lesions (spots that appear as 'holes' on a standard bone x-ray), and skin lesions. There are four basic clinical variants of ATL: acute (60% of cases), lymphomatous (20 % of cases), chronic (10% of cases) and smoldering (10% of cases).
What are the alternative names for Adult T-Cell Leukemia?
  • Adult T-cell leukemia/lymphoma
  • ATLL
  • Adult T-cell leukaemia
  • Adult T-cell leukaemia/lymphoma (HTLV-1 positive)
  • Adult T-cell lymphoma
Who are the top Adult T-Cell Leukemia Local Doctors?
Jaroslaw Maciejewski
Elite in Adult T-Cell Leukemia
Dr. Jaroslaw Maciejewski
Hematology
Elite in Adult T-Cell Leukemia
Dr. Jaroslaw Maciejewski
Hematology

Cleveland Clinic

8950 Euclid Ave, 
Cleveland, OH 
216-444-8950
Languages Spoken:
English
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Offers Telehealth

Jaroslaw Maciejewski is a Hematologist in Cleveland, Ohio. Dr. Maciejewski is rated as an Elite provider by MediFind in the treatment of Adult T-Cell Leukemia. His top areas of expertise are Paroxysmal Nocturnal Hemoglobinuria (PNH), Aplastic Anemia, Paroxysmal Cold Hemoglobinuria, Bone Marrow Transplant, and Splenectomy.

Adam P. Siegel
Distinguished in Adult T-Cell Leukemia
Dr. Adam P. Siegel
Hematology | Oncology
Distinguished in Adult T-Cell Leukemia
Dr. Adam P. Siegel
Hematology | Oncology

Vince Lombardi Cancer Clinic

36500 Aurora Dr, 
Summit, WI 
262-434-8800
Languages Spoken:
English
See accepted insurances
Offers Telehealth

Adam Siegel is a Hematologist and an Oncologist in Summit, Wisconsin. Dr. Siegel is rated as a Distinguished provider by MediFind in the treatment of Adult T-Cell Leukemia. His top areas of expertise are Chronic T-Cell Leukemia (CTCL), Adult T-Cell Leukemia, Angiosarcoma, and Inflammatory Breast Cancer.

 
 
 
 
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Masao Matsuoka
Elite in Adult T-Cell Leukemia
Masao Matsuoka
Elite in Adult T-Cell Leukemia
Masao Matsuoka
Kumamoto, JP 

Masao Matsuoka practices in Kumamoto, Japan. Mr. Matsuoka is rated as an Elite expert by MediFind in the treatment of Adult T-Cell Leukemia. His top areas of expertise are Adult T-Cell Leukemia, Leukemia, HTLV-1 Associated Myelopathy, Vitrectomy, and Trabeculectomy.

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What are the latest Adult T-Cell Leukemia Clinical Trials?
National Longitudinal Cohort of Hematological Diseases (NICHE)
National Longitudinal Cohort of Hematological Diseases (NICHE)
Enrollment Status: Recruiting
Publish Date: February 12, 2026

Summary: Background Hematological diseases are disorders of the blood and hematopoietic organs. The current hematological cohorts are mostly based on single-center or multi-center cases, or cohorts with limited sample size in China. There is a lack of comprehensive and large-scale prospective cohort studies in hematology. The purpose of this study is to analyze the incidence and risk factors of major blood...

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A Phase II Study Evaluating the Efficacy of Ruxolitinib in Patients With T-Cell Large Granular Lymphocytic Leukemia (T-LGLL)
A Phase II Study Evaluating the Efficacy of Ruxolitinib in Patients With T-Cell Large Granular Lymphocytic Leukemia (T-LGLL)
Enrollment Status: Recruiting
Publish Date: February 10, 2026
Intervention Type: Drug
Study Phase: Phase 2

Summary: This phase II trial tests whether ruxolitinib works to shrink tumors in patients with T-cell large granular lymphocyte leukemia. Ruxolitinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.

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Who are the sources who wrote this article ?

Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center