Condition 101 About Adult T-Cell Leukemia

What is the definition of Adult T-Cell Leukemia?

Adult T-cell leukemia/lymphoma (ATL) is is a rare and aggressive T-cell lymphoma that is linked to infection by the human T-cell lymphotropic virus 1 (HTLV-1). The exact mechanism by which HTLV-I infection causes the ATL is unknown. The clinical features of ATL include generalized swelling of the lymph nodes (lymphadenopathy), increased liver and spleen size (hepatosplenomegaly), immunosuppression, high levels of calcium in the blood, lytic bone lesions (spots that appear as “holes” on a standard bone x-ray), and skin lesions.  There are four basic clinical variants of ATL: acute (60% of cases), lymphomatous (20 % of cases), chronic (10% of cases) and smoldering (10% of cases). The best treatment for these patients is unclear and patients should be enrolled in clinical trials whenever possible. Medication may include CHOP chemotherapy (cyclophosphamide, doxorubicin, vincristine and prednisone) or EPOCH (etoposide, vincristine, doxorubicin, cyclophosphamide and prednisone). In some patients, a bone marrow transplant may be recommended.

What are the alternative names for Adult T-Cell Leukemia?

  • ATLL
  • Adult T-cell leukaemia
  • Adult T-cell leukaemia/lymphoma (HTLV-1 positive)
  • Adult T-cell lymphoma

Latest Advances On Adult T-Cell Leukemia

  • Condition: Mature B-Cell Lymphoma and Burkitt Lymphoma
  • Journal: Hematology. American Society of Hematology. Education Program
  • Treatment Used: Chimeric Antigen Receptor (CAR) T Cells
  • Number of Patients: 0
  • Published —
This article assessed chimeric antigen receptor (CAR) T-cell therapies for the treatment of pediatric patients with relapsed/refractory mature B-cell lymphomas.
  • Condition: Adult T-Cell Leukemia/Lymphoma with Severe Hand-Foot Syndrome
  • Journal: Gan to kagaku ryoho. Cancer & chemotherapy
  • Treatment Used: Modified LSG15 Regimen].
  • Number of Patients: 1
  • Published —
This case report describes a 56-year-old woman diagnosed with acute adult T-cell leukemia/lymphoma treated with a modified LSG15 regimen who developed hand-foot syndrome (HFS) treated with heparin analog cream and betamethasone butyrate propionate ointment.

Clinical Trials For Adult T-Cell Leukemia

Clinical Trial
  • Status: Not yet recruiting
  • Phase: Phase 2
  • Intervention Type: Drug, Procedure, Biological
  • Participants: 48
  • Start Date: April 30, 2021
A Phase 2 Study of Cytokine-induced Memory-like NK Cells in Combination With Chemotherapy in Pediatric Patients With Refractory or Relapsed AML