Learn About Adult T-Cell Leukemia

View Main Condition: Leukemia

What is the definition of Adult T-Cell Leukemia?
Adult T-cell leukemia/lymphoma (ATL) is is a rare and aggressive T-cell lymphoma that is linked to infection by the human T-cell lymphotropic virus 1 (HTLV-1). The exact mechanism by which HTLV-I infection causes the ATL is unknown. The clinical features of ATL include generalized swelling of the lymph nodes (lymphadenopathy), increased liver and spleen size (hepatosplenomegaly), immunosuppression, high levels of calcium in the blood, lytic bone lesions (spots that appear as 'holes' on a standard bone x-ray), and skin lesions. There are four basic clinical variants of ATL: acute (60% of cases), lymphomatous (20 % of cases), chronic (10% of cases) and smoldering (10% of cases).
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What are the alternative names for Adult T-Cell Leukemia?
  • Adult T-cell leukemia/lymphoma
  • ATLL
  • Adult T-cell leukaemia
  • Adult T-cell leukaemia/lymphoma (HTLV-1 positive)
  • Adult T-cell lymphoma
Who are the top Adult T-Cell Leukemia Local Doctors?
TK
Dr. Tapan M. Kadia
Oncology | Hematology Oncology | Hematology
Elite
Highly rated in
37
conditions
Oncology
Hematology Oncology
Hematology

University of Texas System

Physicians Referral Service

1515 Holcombe Blvd, 
Houston, TX 

Tapan Kadia is an Oncologist and a Hematologist Oncology expert in Houston, Texas. Kadia has been practicing medicine for over 22 years and is rated as an Elite expert by MediFind in the treatment of Adult T-Cell Leukemia. He is also highly rated in 37 other conditions, according to our data. His top areas of expertise are Acute Myeloid Leukemia (AML), Leukemia, Myelodysplastic Syndrome (MDS), Bone Marrow Aspiration, and Bone Marrow Transplant. Kadia is currently accepting new patients.

ER
Dr. Elizabeth A. Raetz
Pediatric Hematology Oncology | Pediatrics
Elite
Highly rated in
6
conditions
Pediatric Hematology Oncology
Pediatrics

NYC Health and Hospitals

160 E 32nd St, 
New York, NY 

Elizabeth Raetz is a Pediatric Hematologist Oncology specialist and a Pediatrics expert in New York, New York. Raetz has been practicing medicine for over 31 years and is rated as an Elite expert by MediFind in the treatment of Adult T-Cell Leukemia. She is also highly rated in 6 other conditions, according to our data. Her top areas of expertise are Acute Lymphoblastic Leukemia (ALL), Leukemia, Adult T-Cell Leukemia, Infantile Neutropenia, and Bone Marrow Transplant. Raetz is currently accepting new patients.

 
 
 
 
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AU
Atae H. Utsunomiya
Elite
Highly rated in
9
conditions

Imamura Bun-In Hospital

Kagoshima, JP 

Atae Utsunomiya practices in Kagoshima, Japan. Utsunomiya is rated as an Elite expert by MediFind in the treatment of Adult T-Cell Leukemia. They are also highly rated in 9 other conditions, according to our data. Their top areas of expertise are Adult T-Cell Leukemia, Leukemia, HTLV-1 Associated Myelopathy, Peripheral T-Cell Lymphoma, and Bone Marrow Transplant.

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What are the latest Adult T-Cell Leukemia Clinical Trials?
A Multicenter Study to Evaluate Next-Generation Sequencing (NGS) Testing and Monitoring of B-Cell Recovery to Guide Management Following Chimeric Antigen Receptor T-cell (CART) Induced Remission in Children and Young Adults With B Lineage Acute Lymphoblastic Leukemia
Enrollment Status: Not yet recruiting
Publish Date: February 15, 2023
Intervention Type: Diagnostic Test
Study Phase: Not Applicable

Background: Chimeric antigen receptor T-cell (CART) therapy is a form of immunotherapy which can be used to treat people with relapsed B-ALL. For those who achieve remission after CART alone, it may cure up to 50% of people who receive this therapy. However, for people who relapse after CART, it can be hard to achieve remission again. In patients where CART fails, stem cell transplant (HCT) can be used to pre...

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Phase II Trial of LMB-2, Fludarabine and Cyclophosphamide for Adult T-Cell Leukemia
Who is this study for: Patients with adult T-Cell leukemia
Enrollment Status: Active, not recruiting
Publish Date: February 14, 2023
Intervention Type: Drug
Study Drugs: LMB-2FludarabineCyclophosphamide
Study Phase: Phase 1/Phase 2

Summary: BACKGROUND: Cluster of differentiation 25 (CD25) (p55, Tac or interleukin 2 receptor (IL2R) alpha) is strongly expressed in virtually 100% of patients with adult T-cell leukemia/lymphoma (ATL), a highly aggressive human T-lymphotropic virus type 1 (HTLV-1) related malignancy responding poorly to chemotherapy. In ATL, the humanized anti-CD25 monoclonal antibody (Mab) daclizumab produced 13-14% resp...

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Who are the sources who wrote this article ?

Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center

What are the Latest Advances for Adult T-Cell Leukemia?
Chimeric Antigen Receptor T-cell Therapy for Acute Myeloid Leukemia.
Condition: Acute Myeloid Leukemia (AML)
Journal: Hematology/oncology and stem cell therapy
Treatment Used: Chimeric Antigen Receptor (CAR) T-Cell Therapy
Number of Patients: 0
Published: December 20, 2022
Current status and future perspective of CAR T-cell therapy for acute myeloid leukemia.
Condition: Acute Myeloid Leukemia (AML)
Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology
Treatment Used: CAR T-Cell Therapy
Number of Patients: 0
Published: November 09, 2022
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Extracorporeal cytokine removal in chimeric antigen receptor T-cell therapy associated cytokine release syndrome in patient with acute lymphoblastic leukemia. Case report.
Condition: B-Cell Acute Lymphoblastic Leukemia/Cytokine Release Syndrome/Shock/Multiple Orgnan Failure
Journal: Terapevticheskii arkhiv
Treatment Used: Cytokine Removal and Hemodiafiltration Plus CAR-T Therapy
Number of Patients: 1
Published: October 26, 2022
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