Age-Related Macular Degeneration (ARMD) Clinical Trials

Find Age-Related Macular Degeneration (ARMD) Clinical Trials Near You

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A Phase 3, Randomized, Double-Masked, Active-Controlled Trial of a Single Intravitreal Injection of 4D-150 in Adults With Macular Neovascularization Secondary to Age-Related Macular Degeneration

Status: Recruiting
Location: See all (99) locations...
Intervention Type: Biological
Study Type: Interventional
Study Phase: Phase 3
SUMMARY

A Phase 3, Randomized, Double-Masked, Active-Controlled Trial in Adults with Macular Neovascularization Secondary to Age-Related Macular Degeneration

Eligibility
Participation Requirements
Sex: All
Minimum Age: 50
Healthy Volunteers: f
View:

• ≥50 years of age at time of consent

• Treatment naïve MNV secondary to nAMD in the study eye

• Active subfoveal MNV or juxtafoveal/ extrafoveal MNV with a subfoveal component (where activity is defined as evidence of SRF, IRF, subretinal hyperreflective material, or leakage) identified by fluorescein angiography (FA) or spectral domain optical coherence tomography (SD-OCT), in the study eye, at the Screening Visit confirmed by the Reading Center

• Demonstrated clinical response to aflibercept and functional stability in the study eye as confirmed by the Reading Center

• BCVA between 25 and 78 ETDRS letters, inclusive (20/320-20/32 Snellen equivalent) in the study eye at the Screening Visit

• CST less than or equal to 500 microns in the study eye at screening visit, confirmed by the central reading center

Locations
United States
Arkansas
Retina Partners of Northwest Arkansas
RECRUITING
Springdale
Arizona
Barnet Dulaney Perkins Eye Center
RECRUITING
Phoenix
Retinal Research Institute, LLC
RECRUITING
Scottsdale
California
California Retina Consultants
RECRUITING
Bakersfield
Retina Vitreous Associates Medical Group
RECRUITING
Beverly Hills
The Retina Partners
RECRUITING
Encino
Retina Associates of Southern California
RECRUITING
Huntington Beach
Loma Linda University Faculty Medical Clinics
NOT_YET_RECRUITING
Loma Linda
Jules Stein Eye Institute
NOT_YET_RECRUITING
Los Angeles
Northern California Retina Vitreous Associates
RECRUITING
Mountain View
Gavin Herbert Eye Institute
NOT_YET_RECRUITING
Orange
Retina Consultants of San Diego
NOT_YET_RECRUITING
Poway
Kaiser Permanente-Riverside Medical Center
NOT_YET_RECRUITING
Riverside
Retinal Consultants Medical Group Inc
RECRUITING
Sacramento
Retinal Consultants Medical Group Inc
RECRUITING
Sacramento
Orange County Retina Medical Group
RECRUITING
Santa Ana
California Retina Consultants - Santa Barbara
RECRUITING
Santa Barbara
Bay Area Retina Associates
RECRUITING
Walnut Creek
Colorado
University of Colorado, Denver
RECRUITING
Aurora
Retina Consultants of Southern Colorado
NOT_YET_RECRUITING
Colorado Springs
RSC Research, LLC
RECRUITING
Denver
Connecticut
Connecticut Eye Consultants
RECRUITING
Danbury
Florida
Rand Eye Institute
RECRUITING
Deerfield Beach
Retina Group of Florida
RECRUITING
Fort Lauderdale
Vitreo Retinal Associates
RECRUITING
Gainesville
Florida Retina Institute - Jacksonville
RECRUITING
Jacksonville
Florida Retina Consultants
RECRUITING
Lakeland
Florida Retina Institute
RECRUITING
Orlando
Retina Specialty Institute
RECRUITING
Pensacola
Retina Associates of Sarasota
RECRUITING
Sarasota
Retina Vitreous Associates of Florida
RECRUITING
St. Petersburg
East Florida Eye Institute
RECRUITING
Stuart
Georgia
Southeast Retina Center
RECRUITING
Augusta
Georgia Retina PC
RECRUITING
Marietta
Hawaii
Retina Consultants of Hawaii
RECRUITING
‘aiea
Illinois
University of Chicago
NOT_YET_RECRUITING
Chicago
Retina Associates - Elmhurst
RECRUITING
Elmhurst
University Retina and Macula Associates, PC
RECRUITING
Oak Forest
Illinois Retina Associates
NOT_YET_RECRUITING
Oak Park
Indiana
Midwest Eye Institute
RECRUITING
Carmel
Kentucky
Retina Associates of Kentucky
RECRUITING
Lexington
Massachusetts
New England Retina Consultants
RECRUITING
Springfield
Maryland
Wilmer Eye Institute John's Hopkins University
NOT_YET_RECRUITING
Baltimore
Retina Group of Washington
RECRUITING
Chevy Chase
Cumberland Valley Retina Consultants PC
RECRUITING
Hagerstown
Mid Atlantic Retina Specialists - Hagerstown
RECRUITING
Hagerstown
MD Medical Research
NOT_YET_RECRUITING
Waldorf
Maine
Maine Eye Center
NOT_YET_RECRUITING
Portland
Missouri
The Retina Institute
RECRUITING
St Louis
Mississippi
Mississippi Retina Associates
RECRUITING
Madison
Deep Blue Retina Clinical Research
RECRUITING
Southaven
North Carolina
Western Carolina Retinal Associate PA
RECRUITING
Asheville
Duke Eye Center
NOT_YET_RECRUITING
Durham
North Carolina (NC) Retina Associates
RECRUITING
Wake Forest
Atrium Health Wake Forest Baptist Medical Center
NOT_YET_RECRUITING
Winston-salem
New Jersey
Envision Ocular, LLC
RECRUITING
Bloomfield
NJ Retina
RECRUITING
Edison
NJ Retina
NOT_YET_RECRUITING
Teaneck
New Mexico
Eye Associates of New Mexico Vision Research Center
RECRUITING
Albuquerque
Nevada
Sierra Eye Associates
RECRUITING
Reno
New York
Retina-Vitreous Surgeons of Central New York
RECRUITING
Liverpool
Vitreous Retina Macula Consultants of New York
RECRUITING
New York
Retina Associates of Western New York
RECRUITING
Rochester
Ohio
Cole Eye Institute
NOT_YET_RECRUITING
Cleveland
Retina Associates of Cleveland
RECRUITING
Cleveland
Retina Associates of Cleveland
RECRUITING
Youngstown
Oklahoma
Retina Vitreous Center
RECRUITING
Edmond
Oregon
Verum Research, LLC
RECRUITING
Eugene
EyeHealth Northwest Peterkort
RECRUITING
Portland
Pennsylvania
Mid Atlantic Retina
RECRUITING
Bethlehem
Erie Retina Research
RECRUITING
Erie
The Scheie Eye Institute
RECRUITING
Philadelphia
South Carolina
Charleston Neuroscience Center
RECRUITING
Charleston
Charleston Neuroscience Institute
RECRUITING
Ladson
Palmetto Retina Center
RECRUITING
West Columbia
South Dakota
Black Hills Regional Eye Institute
RECRUITING
Rapid City
Texas
Retina Research Institute of Texas
RECRUITING
Abilene
Texas Retina Associates
RECRUITING
Arlington
Austin Clinical Research
RECRUITING
Austin
Austin Research Center for Retina
RECRUITING
Austin
Austin Retina Associates
NOT_YET_RECRUITING
Austin
Retina & Vitreous of Texas, PLLC
RECRUITING
Bellaire
Retina Consultants of Houston
RECRUITING
Bellaire
Texas Retina Center
RECRUITING
Houston
RCTX - Westover Hills Retina Center
RECRUITING
San Antonio
Retina Associates of South Texas PA
RECRUITING
San Antonio
Retina Consultants of Texas San Antonio
RECRUITING
San Antonio
Retina Consultants of Texas
RECRUITING
The Woodlands
Strategic Clinical Research Group, LLC
RECRUITING
Willow Park
Virginia
Retina Group of Washington
RECRUITING
Fairfax
Piedmont Eye Center
RECRUITING
Lynchburg
Retina Institute of Virginia
RECRUITING
Richmond
Washington
Spokane Eye
NOT_YET_RECRUITING
Spokane
Wisconsin
Eye Clinic of Wisconsin
RECRUITING
Wausau
Other Locations
Canada
Calgary Retina Consultants
NOT_YET_RECRUITING
Calgary
Retina Surgical Associates
NOT_YET_RECRUITING
New Westminster
St. Michaels Hospital
NOT_YET_RECRUITING
North York
Retina Institute of Ottawa, Inc.
NOT_YET_RECRUITING
Ottawa
Krembil Neuroscience Centre
NOT_YET_RECRUITING
Toronto
Contact Information
Primary
4DMT Patient Advocacy
clinicaltrials@4DMT.com
(888) 748-8881
Time Frame
Start Date: 2025-03-03
Estimated Completion Date: 2028-06
Participants
Target number of participants: 400
Treatments
Experimental: 4D-150 IVT (3E10 vg/eye)
Active_comparator: Aflibercept (AFLB) 2 mg IVT
Related Therapeutic Areas
Late-Onset Retinal Degeneration
Age-Related Macular Degeneration (ARMD)
Sponsors
Leads: 4D Molecular Therapeutics

This content was sourced from clinicaltrials.gov

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