Phenotypic and Transcriptomic Description of Megakaryocytes in Sickle Cell Patient
Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY
Sickle cell disease is the most common inherited blood disorder in the world. Chronic hemolysis induces platelet activation and chronic inflammation. Platelets and megakaryocyte, as medullar platelets precursors, are known to play a role in innate immunity. Little is known about the role of megakaryocytes at basal state and during acute complication in sickle cell disease patients. The aim of this study is to evaluate the role of megakaryocytes in sickle cell disease.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Sickle cell disease SS or S-béta° thalassemia
• Patient at steady state since at least 1 year or at steady state (without crisis), or during vaso-occlusive crisis or during acute chest syndrome
• Age \> 18 years old
Locations
Other Locations
France
CHU de Toulouse
RECRUITING
Toulouse
Contact Information
Primary
Pierre COUGOUL, MD
cougoul.pierre@iuct-oncopole.fr
0531156265
Time Frame
Start Date: 2025-03-13
Estimated Completion Date: 2028-04-01
Participants
Target number of participants: 40
Treatments
Sickle cell disease patients at rest since at least 1 year
Patient at steady state since at least 1 year
Sickle cell disease patients at rest
Patient at steady state (without crises)
Vaso-occlusive crisis
Sickle cell disease patients during vaso-occlusive crisis
Acute chest syndrome
Sickle cell disease patients during acute chest syndrome
Related Therapeutic Areas
Sponsors
Leads: University Hospital, Toulouse