Magnetic Resonance Imaging in High Risk Patients for the Development of Diffuse Idiopathic Skeletal Hyperostosis (DISH)

Status: Unknown
Location: See location...
Intervention Type: Diagnostic test, Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Diffuse idiopathic skeletal hyperostosis (DISH) is a poorly understood, systemic condition characterized by progressive calcification and ossification of ligaments and entheses. The current classification criteria allow diagnosing the disease in its late course, when significant bony overgrowth already involves the vertebral column and the appendicular skeleton. The research of the pathogenic mechanisms in DISH, is significantly hampered by the late diagnosis resulting from this definition.Based on recent MRI studies in both axial spondyloarthritis (axSpA) and in DISH, it seems that changes similar to the classical early inflammatory changes described in axSpA, can be detected in patients with DISH. We therefore hypothesize, that patients with metabolic syndrome without radiographic evidence for spinal DISH, might exhibit early MRI changes. If this hypothesis proves to be correct, early diagnosis and research of the possible pathogenetic mechanisms at this early stage might be very rewarding in investigations of the early aberrations of the entheses homeostasis and eventually early, more targeted therapeutic interventions. The study will examine MRI changes in patients, in their 5th decade of life, with high risk for the development of DISH (ie diabetes mellitus, metabolic syndrome) compared with patients who don't have this risk.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 40
Maximum Age: 49
Healthy Volunteers: t
View:

• Meet the NCEP 3 criteria for metabolic syndrome and/or have type 2 diabetes mellitus (9).

⁃ Age 40-49 years

Locations
Other Locations
Israel
HaEmek MC and Chaim Sheba MC
RECRUITING
Afula
Contact Information
Primary
Reuven Mader, MD
mader_r@clalit.org.il
972-4-6494354
Backup
Irina Novofastovski, MD
irina_no@clalit.org.il
972-4-6494354
Time Frame
Start Date: 2018-08-01
Completion Date: 2022-12-30
Participants
Target number of participants: 30
Treatments
Experimental: study group
Thoracic spine x-rays+whole spine MRI blood tests constitutional and demographic data collection
Active_comparator: control group
Thoracic spine x-rays+whole spine MRI blood tests constitutional and demographic data collection
Sponsors
Leads: HaEmek Medical Center, Israel
Collaborators: The Chaim Sheba Medical Center

This content was sourced from clinicaltrials.gov

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