A Randomized, Double-blind, Placebo-controlled, Study to Identify the Opioid-sparing Effects, and Pain-reduction Potential of Low Dose Ketamine on Patients Undergoing TEVAR Procedures Receiving NCI
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2
SUMMARY
The objective of this study is to identify the opioid-sparing effects, and pain-reduction potential of low dose, sub-dissociative ketamine on patients undergoing thoracic endovascular aortic repair (TEVAR) procedures receiving naloxone continuous infusion (NCI).
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 90
Healthy Volunteers: f
View:
• willing to give informed consent
• scheduled for elective thoracic aorta repair or thoracoabdominal aortic repair
• requires naloxone continuous infusion for spinal prophylaxis
Locations
United States
Kentucky
University of Kentucky Medical Center
RECRUITING
Lexington
Contact Information
Primary
Eric Johnson, PharmD
eric.johnson@uky.edu
8593235722
Time Frame
Start Date: 2020-12-08
Estimated Completion Date: 2027-08
Participants
Target number of participants: 30
Treatments
Placebo_comparator: Standard of Care
Participants in this group will receive standard of care as well as a saline infusion during the study period.
Experimental: Sub-Dissociative Ketamine
Participants in this group will receive standard of care as well as a continuous ketamine infusion at the induction of anesthesia and for 48 hours postoperatively.
Related Therapeutic Areas
Sponsors
Leads: Sam Tyagi