Transcatheter AortiC Valve Implantation in aorTic stenosIs CardiogenIc Shock - The TACTICS Study - A Randomized Controlled Trial
The goal of this clinical trial is to learn if acute transcatheter aortic valve implantation (TAVI) is superior to standard treatment (stabilization in an intensive care unit and TAVI subsequently) to treat cardiogenic shock in patients with critical severe aortic stenosis. The main questions it aims to answer are: • Does acute TAVI increase survival compared with standard treatment? Participants will: * Undergo either TAVI within 12 hours after admission or stabilization and TAVI 72 hours or more after admission * Visit an outpatient clinic and be evaluated for quality of life and heart function
• Aortic valve area less than 1cm2
⁃ AND
⁃ Cardiogenic Shock defined as:
• Peripheral signs of tissue hypoperfusion (arterial blood lactate ≥2.5mmol/l) AND
• Systolic blood pressure \< 100 mmHg and/or need for vasopressor therapy (dopamine/ norepinephrine or epinephrine) AND
• Left ventricular ejection fraction ≤ 45%
⁃ OR
⁃ \- Syncope/resuscitation (mechanical ventilation)