Coronary Epicardial and Microcirculatory Determinants of Ventricular Tachycardia Tolerability

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY

The goal of this observational study is to learn about the factors which determine how well ventricular tachycardia (VT) is tolerated. The main questions it aims to answer are: 1. What impact does coronary artery disease have on the ability for a patient to tolerate VT? 2. Does treatment of coronary artery disease with stents improve the tolerability of VT? Participants who are undergoing a clinically indicated coronary angiogram or coronary angioplasty procedure will have measurements of blood pressure, coronary pressure and coronary flow made during pacing at a range of heart rates.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Able to give valid consent

• Referred for coronary angiography or coronary angioplasty

• Suitable for percutaneous physiological interrogation and PCI when clinically indicated

Locations
Other Locations
United Kingdom
Imperial College NHS Foundation Trust
RECRUITING
London
Contact Information
Primary
Rahul Bahl
r.bahl@imperial.ac.uk
+44 20 7594 1093
Backup
Ricardo Petraco
r.petraco@imperial.ac.uk
+44 20 7594 1093
Time Frame
Start Date: 2023-08-01
Estimated Completion Date: 2026-02-02
Participants
Target number of participants: 70
Treatments
Controls
10 patients with unobstructed coronary arteries, normal microvascular function and normal LV function.
Coronary artery disease
25 patients with severe, single-vessel coronary artery disease of the proximal LAD or proximal other dominant vessel awaiting PCI.
Microvascular dysfunction
15 patients with without severe disease in any coronary artery, impaired microvascular function and normal LV function.
Heart failure
20 patients with LV systolic dysfunction (LVEF\<40%).
Sponsors
Leads: Imperial College London

This content was sourced from clinicaltrials.gov