Long Term Registry of Patients With Left Ventricular Non-Compaction and Predictors of Adverse Outcomes

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

The goal of this study is to learn more about the risk factors associated with left ventricular non-compaction (LVNC) and the predictors of adverse outcomes associated with LVNC. The main questions this study aims to answer are as follows. * Are there any genetic mutations that impact the risk of LVNC patients developing ventricular arrhythmias? * Does LV myocardial strain increase risk stratification in the LVNC population with or without genetic mutations? * What are some of the determinants that cause LV dysfunction in LVNC? * What are other risk stratifiers (ex. premature ventricular contraction (PVC) burden on Holter, non-sustained ventricular tachycardia (NSVT) on stress test) that lead to an outcome of ICD implantation? Participants will have their medical records accessed annually for a span of ten years, either prospectively or retrospectively depending on whether they are being actively followed by physicians at the Inherited Arrhythmia Clinic or not, to evaluate LVNC progression over time. This data will be stored in a large clinical registry with the London Heart Rhythm Program at the London Health Sciences Centre, University Hospital Campus.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
View:

⁃ Patients must meet the following criteria in order to be included in the study.

• Have a confirmed diagnosis of LVNC (between 2010-2020 for patients in the retrospective cohort only)

• Be over 18 years of age

Locations
Other Locations
Canada
London Health Sciences Centre - University Hospital
RECRUITING
London
Contact Information
Primary
Dr. Habib Khan
habib.khan@lhsc.on.ca
519-663-3746
Time Frame
Start Date: 2023-09-01
Estimated Completion Date: 2033-08-01
Participants
Target number of participants: 500
Treatments
Retrospective Cohort
Individuals in this group were previously seen by physicians at the Inherited Arrhythmia Clinic at University Hospital, London Health Sciences Centre, yet are no longer being actively followed here anymore. These patients will have their data retrospectively obtained annually, ten years into the past, to collect data on key variables providing insight on LVNC progression over time.
Prospective Cohort
Patients being actively followed up by physicians at the Inherited Arrhythmia Clinic will be approached either in person or via e-mail for consent and enrollment into this study. These patients will have their medical charts accessed annually to collect data on key variables providing insight on LVNC progression over time.
Sponsors
Leads: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

This content was sourced from clinicaltrials.gov