Arrhythmogenic Right Ventricular Cardiomyopathy

Condition 101

What is the definition of Arrhythmogenic Right Ventricular Cardiomyopathy?

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart condition in which the muscle of the right ventricle of the heart is replaced by fat and/or scar tissue. The condition is progressive and over time the right ventricle loses the ability to pump blood. I ...

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What are the alternative names for Arrhythmogenic Right Ventricular Cardiomyopathy?

  • ARVD
  • ARVC
  • Arrhythmogenic right ventricular dysplasia

Is Arrhythmogenic Right Ventricular Cardiomyopathy an inherited disorder?

The genetic basis of ARVC is complex and not fully understood. There are different ways in which ARVC can be inherited. The most common pattern of inheritance for ARVC is autosomal dominant. This means that a mutation in only one copy of the disease-causing gene is sufficient to cause the condition. An individual with an autosomal dominant condition has a 50% risk to pass the mutation on to each child. Other individuals with ARVC have an autosomal recessive form. This means mutations in both copies of the gene must be present to have a predisposition to ARVC. Parents of an individual with an autosomal recessive condition each carry one mutated copy of the gene and are referred to as carriers. When two carriers of an autosomal recessive condition have children, each child has a 25% risk to inherit mutations and be affected. Genetic testing can help determine which pattern of inheritance an affected individual has.

Latest Research

Latest Advance
  • Condition: Inherited Cardiac Arrhythmia Syndrome in Children
  • Journal: Zhonghua er ke za zhi = Chinese journal of pediatrics
  • Treatment Used: Implantable Cardioverter Defibrillator (ICD) Implantation
  • Number of Patients: 30
  • Published —
This study analyzed and summarized the diagnosis and treatment experience of common inherited cardiac arrhythmia (heart quivering) syndrome in pediatric patients, and explored the most appropriate therapy.

Clinical Trials

Clinical Trial
  • Status: Recruiting
  • Participants: 1000
  • Start Date: October 2016
Metabolomic Study of Patients With Cardiomyopathy in China
Clinical Trial
  • Status: Recruiting
  • Participants: 6000
  • Start Date: January 2016
The Mayo Clinic Arrhythmogenic Ventricular Cardiomyopathy Registry and Biobank
Clinical Trial
  • Status: Recruiting
  • Participants: 2000
  • Start Date: July 1, 2015
An Integrative-omics Study to Identify New Biomarkers of Cardiomyopathy Patients in China
Clinical Trial
  • Status: Recruiting
  • Participants: 200
  • Start Date: January 2013
Risk Stratification in Children and Adolescents With Primary Cardiomyopathy