Phosphodiesterase 4 Gene Variant and Salbutamol Response in Persistent Childhood Asthma
Status: Unknown
Location: See location...
Intervention Type: Drug
Study Type: Observational
SUMMARY
This study is designed to investigate whether the Phosphodiesterase 4 gene variability could be implicated in the salbutamol responsiveness in asthmatic children.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 6
Maximum Age: 18
Healthy Volunteers: f
View:
• Children 6-18 years
• Asthma: confirmed asthma symptoms (wheeze, cough, dyspnea, chest tightness) and evidence for variable airflow limitation (≥ 12% increase in post bronchodilator FEV1, or ≥ 20% decrease in FEV1 post methacholine)
• Spirometry prescribed for follow-up
• Airflow limitation: FEV1\<80% and/or FEV1/FVC \<80 pre-bronchodilator
Locations
Other Locations
France
Hôpital Necker -Enfants Malades
Paris
Time Frame
Start Date: 2018-11-25
Completion Date: 2023-03
Participants
Target number of participants: 99
Related Therapeutic Areas
Sponsors
Leads: Assistance Publique - Hôpitaux de Paris