Health for Hungary - Longitudinal Collection of Blood Samples and Corresponding Data for Longterm Evaluation of Innovative Diagnostic Techniques in Subjects Without Clinically Relevant Disorders at Baseline to Institute Molecular Fingerprinting Reference Norms
Design: Single-country, multicenter, prospective, longitudinal survey.
Objectives: The study aims to establish reference ranges of blood parameters using routine clinical blood tests and high-information-content methods, including proteomics, metabolomics and the so-called infrared molecular fingerprinting. The study also aims to identify novel biomarkers of major non-communicable diseases, including atherosclerotic cardiovascular disease, cancer, diabetes and chronic respiratory disease.
• Signed informed consent form (ICF) of the study.
• Age \> 40 years.
• Willingness to fill in the study questionnaire.
• No clinically relevant symptoms as assessed by the investigator, subjects with existing medical conditions may be eligible given that they are symptom free and that full treatment of the condition is medically confirmed.
• Willingness to participate in future visits.
• Signed informed consent form (ICF) of the study.
• Age \> 50 years.
• Willingness to fill in the study questionnaire.
• Willingness to participate in future visits and medical investigations, the presence of at least 2 of the following 3 risk factors (inclusion criteria #5-7):
• Hypertension, receiving antihypertensive treatment.
• Dyslipidemia/ Hypercholesterolemia (\>5.2mmol/L total cholesterol level), on or not on statin-treatment.
• Active or former smoker, with smoking history of at least 20 pack-years, and/or the presence of intermediate lung nodule on prior LDCT testing.
• No clinically relevant symptoms as assessed by the investigator; subjects with existing medical conditions may be eligible given that they are symptom free and that treatment of the condition is well documented.