Atrial Fibrosis in Obstructive Sleep Apnea Patients: A Pilot Study

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The investigators hypothesize that Obstructive Sleep Apnea (OSA) is an independent risk factor for atrial fibrosis development. The investigators aim to prove the presence of atrial fibrosis on Delayed Enhancement Magnetic Resonance Imaging (DE-MRI) in OSA patients without atrial fibrillation (AF).

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: t
View:

⁃ Group A: 10 patients 18-75-year-old With mild OSA (5\<AHI\<15), confirmed by polysomnography. No previous AF diagnosis on the medical chart

⁃ Group B: 10 patients 18-75-year-old With moderate OSA (15\<AHI\<30), confirmed by polysomnography. No previous AF diagnosis on the medical chart

⁃ Group C: 10 patients 18-75-year-old With severe OSA (AHI\>30), confirmed by polysomnography. No previous AF diagnosis on the medical chart

⁃ Group D (mild OSA+ AF): 10 patients 18-75-year-old With mild OSA (5\<AHI\<15), confirmed by polysomnography. Previous AF diagnosis

• In this group, patients with AF and OSA who already have done MRI might be included.

⁃ Group E (severe OSA +AF): 10 patients 18-75-year-old With severe OSA (AHI\>30), confirmed by polysomnography. Previous AF diagnosis

⁃ \*In this group, patients with AF and OSA who already have done MRI might be included.

⁃ Group F (Control): 10 Patients 18-75-year-old No previous OSA and/or AF Diagnosis on the medical chart

Locations
United States
Louisiana
East Jefferson General Hospital
RECRUITING
New Orleans
Tulane University Medical Center
RECRUITING
New Orleans
Contact Information
Primary
Quintrele Jones, MPH
qjones1@tulane.edu
504-988-3063
Backup
Chris Wang, MS
hwang37@tulane.edu
504-988-3065
Time Frame
Start Date: 2021-07-12
Estimated Completion Date: 2025-12
Participants
Target number of participants: 60
Treatments
Experimental: Group A
Mild OSA~* 10 patients diagnosed with mild OSA (5\<AHI\<15) with no atrial fibrillation.~* Diagnosis confirmed through polysomnography\* before enrollment.
Experimental: Group B
Moderate OSA~* 10 patients diagnosed with moderate OSA (15\<AHI\<30) with no atrial fibrillation.~* Diagnosis confirmed through polysomnography\* before enrollment.
Experimental: Group C
Severe OSA~* 10 patients diagnosed with severe OSA (AHI\>30) with no atrial fibrillation.~* Diagnosis confirmed through polysomnography\* before enrollment.
Experimental: Group D
Mild OSA and AF~* At least 10 patients diagnosed with mild OSA (5\<AHI\<15).~* Diagnosis confirmed through polysomnography\* before enrollment.~* Diagnosed with AF.
Experimental: Group E
Severe OSA and AF~* At least 10 patients diagnosed with severe OSA (AHI\>30).~* Diagnosis confirmed through polysomnography\* before enrollment.~* Diagnosed with AF.
Other: Group F
Control - No OSA~10 control patients without OSA and without AF.
Authors
Lilas Dagher, Uzodinma Emerenini
Related Therapeutic Areas
Atrial Fibrillation
Obstructive Sleep Apnea
Sponsors
Leads: Tulane University

This content was sourced from clinicaltrials.gov

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