Biomarker-Guided Optimization of Transcutaneous Vagal Stimulation for Atrial (BiG tVNS-AF)
Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This proposal aims to determine the effects of tVNS on autonomic tone, atrial substrate and neuromodulators in patients with paroxysmal atrial fibrillation (AF), investigate the chronic effects of optimal tVNS on AF burden in patients with paroxysmal AF over a 6-month period, compared with sham stimulation, and identify physiological and biochemical markers of response to chronic tVNS.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 21
Maximum Age: 90
Healthy Volunteers: f
View:
• 1\. Paroxysmal atrial fibrillation
Locations
United States
Oklahoma
University of Oklahoma Health Sciences Center
RECRUITING
Oklahoma City
Contact Information
Primary
Natalia Wells-Serrano
Natalia-WellsSerrano@ouhsc.edu
405-271-4742
Time Frame
Start Date: 2022-09-14
Estimated Completion Date: 2026-05-29
Participants
Target number of participants: 160
Treatments
Active_comparator: Active TENS Stimulation
Sham_comparator: Inactive TENS Stimulation
Related Therapeutic Areas
Sponsors
Leads: University of Oklahoma